Recent advances in 3D bioprinted polysaccharide hydrogels for biomedical applications: A comprehensive review

被引：16

作者：

Damiri, Fouad ^{[1
,2
]}

Fatimi, Ahmed ^{[2
]}

Liu, Yang ^{[3
]}

Musuc, Adina Magdalena ^{[4
]}

Fajardo, Andre R. ^{[5
]}

Gowda, B. H. Jaswanth ^{[6
]}

Vora, Lalitkumar K. ^{[6
]}

Shavandi, Armin ^{[1
]}

Okoro, Oseweuba, V ^{[1
]}

机构：

[1] Univ Libre Bruxelles ULB, Ecole Polytech Bruxelles, 3BIO BioMatter, Ave FD Roosevelt 50,CP 165-61, B-1050 Brussels, Belgium

[2] Sultan Moulay Slimane Univ USMS, Polydisciplinary Fac Beni Mellal FPBM, Dept Chem, Chem Sci & Engn Res Team ERSIC, Beni Mellal 23000, Morocco

[3] Univ South China, Hunan Prov Cooperat Innovat Ctr Mol Target New Dru, Hengyang Med Sch, Hunan Prov Key Lab Tumor Microenvironm Respons Dru, Hengyang 421001, Peoples R China

[4] Ilie Murgulescu Inst Phys Chem, 202 Spl Independentei, Bucharest 060021, Romania

[5] Fed Univ Pelotas UFPel, Lab Tecnol & Desenvolvimento Compositos & Mat Poli, BR-96010900 Pelotas, RS, Brazil

[6] Queens Univ Belfast, Sch Pharm, 97 Lisburn Rd, Belfast BT9 7BL, North Ireland

来源：

CARBOHYDRATE POLYMERS | 2025年 / 348卷

关键词：

Bioinks; Additive manufacturing; Bioprinting; Polysaccharide modification; Tissue engineering; Regenerative medicine; HYALURONIC-ACID; TISSUE; ALGINATE; BIOMATERIALS; CONSTRUCTS; SCAFFOLDS; PULLULAN; STRATEGY; DELIVERY; BIOINKS;

D O I：

10.1016/j.carbpol.2024.122845

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Polysaccharide hydrogels, which can mimic the natural extracellular matrix and possess appealing physicochemical and biological characteristics, have emerged as significant bioinks for 3D bioprinting. They are highly promising for applications in tissue engineering and regenerative medicine because of their ability to enhance cell adhesion, proliferation, and differentiation in a manner akin to the natural cellular environment. This review comprehensively examines the fabrication methods, characteristics, and applications of polysaccharide hydrogeldriven 3D bioprinting, underscoring its potential in tissue engineering, drug delivery, and regenerative medicine. To contribute pertinent knowledge for future research in this field, this review critically examines key aspects, including the chemistry of carbohydrates, manufacturing techniques, formulation of bioinks, and characterization of polysaccharide-based hydrogels. Furthermore, this review explores the primary advancements and applications of 3D-printed polysaccharide hydrogels, encompassing drug delivery systems with controlled release kinetics and targeted therapy, along with tissue-engineered constructs for bone, cartilage, skin, and vascular regeneration. The use of these 3D bioprinted hydrogels in innovative research fields, including disease modeling and drug screening, is also addressed. Despite notable progress, challenges, including modulating the chemistry and properties of polysaccharides, enhancing bioink printability and mechanical properties, and achieving longterm in vivo stability, have been highlighted.

引用

页数：28

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