Protein-bound and free glycation compounds in human milk: A comparative study with minimally processed infant formula and pasteurized bovine milk

被引:0
作者
Arena, Simona [1 ]
De Pascale, Sabrina [1 ]
Ciaravolo, Valentina [1 ]
Monroy, Mariela Mejia [2 ,3 ]
Gouw, Joost W. [4 ]
Stahl, Bernd [4 ]
Bauerl, Christine [5 ]
Collado, Maria Carmen
De Filippo, Carlotta
Scaloni, Andrea [1 ]
Troise, Antonio Dario [1 ]
机构
[1] Natl Res Council ISPAAM CNR, Inst Anim Prod Syst Mediterranean Environm, Prote Metabol & Mass Spectrometry Lab, Portici, Italy
[2] Natl Res Council IBBA CNR, Inst Agr Biol & Biotechnol, Pisa, Italy
[3] Univ Florence, NEUROFARBA Dept, Pharmacol & Toxicol Sect, Florence, Italy
[4] Danone Res & Innovat, NL-3584 CT Utrecht, Netherlands
[5] CSIC, Inst Agrochem & Food Technol, Natl Res Council, Valencia, Spain
基金
欧盟地平线“2020”;
关键词
Human milk; Infant formula; Maillard reaction; Mass spectrometry; N-EPSILON-CARBOXYMETHYLLYSINE; MAILLARD REACTION-PRODUCTS; END-PRODUCTS; BREAST-MILK; MASS-SPECTROMETRY; ENDPRODUCTS; FOOD; N-EPSILON-(CARBOXYMETHYL)LYSINE; STRATEGIES; LYSINE;
D O I
10.1016/j.foodchem.2024.141265
中图分类号
O69 [应用化学];
学科分类号
081704 ;
摘要
The role of the Maillard reaction and the accumulation of non-enzymatic glycation compounds in human milk have been scarcely considered. In this study, we investigated the proteins most susceptible to glycation, the identity of the corresponding modified residues and the quantitative relationship between protein-bound and free glycation compounds in raw human milk and, for comparison, in minimally processed infant formula and pasteurized bovine milk. In human milk, total protein-bound lysine modifications were up to 10% of the counterparts in infant formula, while N epsilon-carboxymethyllysine reached up to 27% of the concentration in the other two products. We demonstrated that the concentration of free pyrraline and methylglyoxalhydroimidazolone were of the same order of magnitude in the three milk types. Our results delineate how the occurrence of some glycation compounds in human milk can be an unavoidable part of the breastfeeding and not an exclusive attribute of infant formulas and pasteurized bovine milk.
引用
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页数:14
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