Reduction of nicotine content in tobacco through microbial degradation: research progress and potential applications

被引：0

作者：

Li, Zi-Jia ^{[2
]}

Yang, Dong-Dong ^{[2
]}

Wei, Zhi-Yun ^{[2
]}

Huang, Jie ^{[1
]}

Chi, Yi-Qian ^{[1
]}

Lu, You-Xuan ^{[1
]}

Yin, Feng-Wei ^{[1
,3
]}

机构：

[1] School of Life Sciences, Taizhou University, Zhejiang, Taizhou

[2] School of Food Science and Pharmaceutical Engineering, Nanjing Normal University, Nanjing

[3] Taizhou Key Laboratory of Biomass Functional Materials Development and Application, Taizhou University, Zhejiang, Taizhou

来源：

Biotechnology for Biofuels and Bioproducts | 2024年 / 17卷 / 01期

关键词：

Biotechnology; Nicotine-degrading microorganisms (NDMs); Novel tobacco products; Tobacco;

D O I：

10.1186/s13068-024-02593-3

中图分类号：

学科分类号：

摘要：

Originally native to South America, tobacco and is now distributed worldwide as a major cash crop. Nicotine is the main harmful component of tobacco leaves, cigarette smoke and tobacco waste, which severely affects not only the flavor of the tobacco leaf, but also causes great damage to human health. As the anti-smoking movement continued to grow since the 1950s, and consumers become more aware of their health and environmental protection, the world tobacco industry has been committed to research, develop and produce low nicotine cigarette products with relatively low risk to human health. Among various approaches, the use of microorganisms to reduce nicotine content and improve tobacco quality has become one of the most promising methods. Due to increasing interest in nicotine-degrading microorganisms (NDMs), this article reviews recent reports on NDMs, nicotine-degrading enzymes, regulation of nicotine-degrading bacterial consortia and optimization of fermentation conditions, aiming to provide updated references for the in-depth research and application of microorganisms for the degradation of nicotine. © The Author(s) 2024.

引用

共 117 条

[1] Pammel L.H., Library C.U., A manual of poisonous plants: chiefly of eastern North America, with brief notes on economic and medicinal plants, and numerous illustrations, (1911)
[2] FAO. Food and Agriculture Organization of the United Nations, (2014)
[3] Hecht S.S., Tobacco smoke carcinogens and lung cancer, J Natl Cancer Inst, 91, pp. 53-74, (1999)
[4] Armstrong D.W., Wang X., Ercal N., Enantiomeric composition of nicotine in smokeless tobacco, medicinal products, and commercial reagents, Chirality, 10, pp. 587-591, (1998)
[5] Thorgeirsson T.E., Geller F., Sulem P., A variant associated with nicotine dependence, lung cancer and peripheral arterial disease, Nature, 452, pp. 638-642, (2008)
[6] Hawkins B.T., Abbruscato T.J., Egleton R.D., Brown R.C., Huber J.D., Campos C.R., Davis T.P., Nicotine increases in vivo blood–brain barrier permeability and alters cerebral microvascular tight junction protein distribution, Brain Res, 1027, pp. 48-58, (2004)
[7] Karina C., Montan M.F., Cassia C.D., Et al., In vitro evaluation of the effect of nicotine, cotinine, and caffeine on oral microorganisms, Can J Microbiol, 54, pp. 501-508, (2008)
[8] Yildiz D.J.T., Nicotine, its metabolism and an overview of its biological effects, Toxicon, 43, pp. 619-632, (2004)
[9] Brunnemann K.D., Prokopczyk B., Djordjevic M.V., Formation and analysis of tobacco-specific N-nitrosamines, Crit Rev Toxicol, 26, pp. 121-137, (1996)
[10] Campain J.A., Nicotine: potentially a multifunctional carcinogen?, Toxicol Sci, 79, pp. 1-3, (2004)

← 1 2 3 4 5 6 7 8 9 10 →