Biomimetically inspired hybrid materials based on silicified collagen

被引：43

作者：

Heinemann, Sascha ^{[1
]}

Ehrlich, Hermann ^{[1
]}

Knieb, Christiane ^{[1
]}

Hanke, Thomas ^{[1
]}

机构：

[1] Max Bergmann Center of Biomaterials and Institute of Materials Science, Dresden University of Technology, Budapester Str. 27, Dresden,D-01069, Germany

来源：

Zeitschrift fuer Metallkunde/Materials Research and Advanced Techniques | 2007年 / 98卷 / 07期

关键词：

Biocompatibility - Collagen - Biomimetics - Silica - Scaffolds (biology) - Chemical analysis - Medical applications - Sol-gels - Compressive strength - Scaffolds - Tensile strength;

D O I：

10.3139/146.101519

中图分类号：

学科分类号：

摘要：

Starting from a natural example, several hybrid materials based on silicified collagen were synthesised under ambient conditions. The biomimetic approach and further steps allowed the production of porous as well as dense constructs whose structural assembly was similar to that observed microscopically in the natural glass fibres made by sponges. Chemical analyses showed the collagen used serving as an organic template that binds silicic acid whose condensation results in local silicification and strengthening of the hybrid. This effect was emphasised by mechanical testing. Compressive strength of the porous scaffolds has been increased by about four times and splitting tensile strength of the xerogels by up to six times due to hybridisation. As the hybrid materials additionally show proper biocompatibility, they seem to be suitable for medical applications, especially as a base material for load-bearing implants.

引用

页码：603 / 608