Based on the pounding phenomenon at expansion joints of irregular girder bridges during earthquakes, a simplified analytical model that considers the effects of two-sided collision was presented. With the time history analysis method of determining the nonlinear seismic responses, the pounding effects of adjacent girders at expansion joints on seismic responses of irregular girder bridges were studied, and the influences on two-sided and one-sided pounding on structural displacements were investigated. The results from the present study may serve as a reference base for seismic design of irregular girder bridges.