Evaluation of vitamin E and calcium effects on fluoride toxicity-induced fertility impairment

被引：1
作者：
Emara A.M. [1 ]
El-Kelany R.S. [1 ]
Elmasry T.A. [2 ]
Elkareb M. [3 ]
机构：
[1] Faculty of Medicine, Departments of Forensic Medicine and Clinical Toxicology, Tanta University, Tanta
[2] Faculty of Pharmacy, Department of Pharmacology and Physiology, Tanta University, Tanta
[3] Faculty of Medicine, Tanta University, Tanta
来源：
Toxicological and Environmental Chemistry | 2010年 / 92卷 / 02期
关键词：
Calcium; Fertility impairment; Fluoride toxicity; Vitamin E;
D O I：
10.1080/02772240902955743
中图分类号：
学科分类号：
摘要：
Chronic fluoride (Fl) toxicity is a serious public health problem globally where drinking water contains more than 1 ppm of Fl. Sodium fluoride (NaF) produced male reproductive system toxicity. The aim of the present study was to evaluate the amelioration of Fl toxicity-induced fertility impairment by vitamin E and calcium during the withdrawal period. The study was carried out on 70 adult male albino rats divided into five main groups: group I control; subdivided into group Ia (maintained on standard diet and water ad libitum for 60 days) and group Ib (maintained on standard diet and water ad libitum for 120 days), group II was administered NaF and subdivided into group IIa(administered NaF for60day and sacrificed) and group IIb (administered NaF for 60 day then maintained on standard diet and water ad libitum for a further 60 days), and treated groups III, IV, and V were administered NaF. Rats were maintained during withdrawal from NaF, on vitamin E(10 mg kg-1 day-1 for 60 days), calcium (50 mg kg-1 day-1orally for 60 days), and both vitamin E and calcium, respectively. The duration of NaF administration was 60 days at a dose 20 mg kg-1 day-1 for all treated groups. The following parameters were determined: body and organ weights, sperm motility, sperm mor-phology, sperm viability, fertility test, and hormone assays: testosterone, in vitro testosterone production, luteinizing hormone, and follicular stimulating hormone. The combined administration of vitamin E and calcium during withdrawal from NaF showed significant improvement from chronic FL-induced toxicity on male reproductive organs. © 2010 Taylor & Francis.
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页码：333 / 345
页数：12
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