The association of exposure to polychlorinated biphenyls with lipid profile and liver enzymes in umbilical cord blood samples

被引：4
作者：
Hjazi A. [1 ]
Hsu C.-Y. [2 ]
Al-Attar W.M. [3 ]
Almajidi Y.Q. [4 ]
Hussien B.M. [5 ,6 ,7 ]
Alzahrani A.A. [8 ]
Kareem A.K. [9 ]
Abdulhussien alazbjee A.A. [10 ]
Meng X. [11 ,12 ,13 ]
机构：
[1] Department of Medical Laboratory Sciences, College of Applied Medical Sciences, Prince Sattam bin Abdulaziz University, Al-Kharj
[2] Department of Pharmacy, Chia Nan University of Pharmacy and Science, Tainan
[3] College of Nursing, Al-Bayan University, Baghdad
[4] Lecturer Dr and Dean Assistant of Baghdad College of Medical Sciences-department of Pharmacy (pharmaceutics), Baghdad
[5] Medical Laboratory Technology Department, College of Medical Technology, The Islamic University, Najaf
[6] Medical Laboratory Technology Department, College of Medical Technology, the Islamic University of Al Diwaniyah, Al Diwaniyah
[7] Medical Laboratory Technology Department, College of Medical Technology, the Islamic University of Babylon, Babylon
[8] Orthopedic Surgeon, Professor Department of Surgery, Taif University
[9] Biomedical Engineering Department, College of Engineering and Technologies, Al-Mustaqbal University, Hillah
[10] Collage of Medicin, Al-Ayen University, Thi-Qar
[11] Hepatobiliary Surgery Department, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing
[12] Hepatobiliary Surgery Department, Hebei Cancer Hospital, Chinese Academy of Medical Sciences, Hebei, Langfang
[13] Jiangsu Center for the Collaboration and Innovation of Cancer Biotherapy, Cancer Institute, Xuzhou Medical College, Jiangsu, Xuzhou
来源：
Chemosphere | 2024年 / 350卷
基金：
中国国家自然科学基金;
关键词：
Dyslipidemia; Infant; Liver; Persistent organic pollutants; Pregnancy;
D O I：
10.1016/j.chemosphere.2023.141096
中图分类号：
学科分类号：
摘要：
Evidence on prenatal exposure to polychlorinated biphenyls (PCBs) and its effects on newborns and potential biological mechanisms is not well defined yet. Therefore, this study aimed to examine whether PCBs are associated with lipid profile and non-invasive markers of hepatocyte injuries in samples of blood obtained from the umbilical cord. This study included 450 mothers-newborn pairs. Umbilical levels of PCBs were measured using Gas Chromatography/Mass Spectrophotometry (GC/MS). Lipid profile including low-density lipoprotein (LDL-C), total cholesterol (TC), triglycerides (TG), and high-density lipoprotein (HDL-C), as well as liver enzymes i.e., alanine amino transferase (ALT), aspartate amino transferase (AST), γ-glutamyl-transferase (GGT) and alkaline phosphatase (ALP) were determined from umbilical cord blood samples. Quantile g-computation analysis was applied to evaluate the collective influence of PCBs on both lipid profiles and liver enzymes, along with the impact of lipid profiles on liver enzymes. Exposure to the mixture of PCBs was significantly associated with increases in ALP, AST, ALT, and GGT levels in cord blood samples, with increments of 90.38 U/L (95%CI: 65.08, 115.70, p < 0.01), 11.88 U/L (95%CI: 9.03, 14.74, p < 0.01), 2.19 U/L (95%CI:1.43, 2.94, p < 0.01), and 50.67 U/L (95%CI: 36.32, 65.03, p < 0.01), respectively. Additionally, combined PCBs exposure was correlated with significant increases in umbilical TG, TC, and LDL-C levels, with values of 3.97 mg/dL (95%CI: 0.86, 7.09, p = 0.01), 6.30 mg/dL (95%CI: 2.98, 9.61, p < 0.01), and 4.63 mg/dL (95%CI: 2.04, 7.23, p < 0.01) respectively. Exposure to the mixture of lipids was linked to elevated levels of AST and GGT in umbilical cord blood samples. Furthermore, a noteworthy mediating role of TC and LDL-C was observed in the association between total PCBs exposure and umbilical cord blood liver enzyme levels. Overall our findings suggested that higher levels of umbilical cord blood PCBs and lipid profile could affect liver function in newborns. © 2024 Elsevier Ltd
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