Bioactivities of Peptides Derived from Hericium erinaceus Proteins by Enzymatic Hydrolysis

被引：1

作者：

Yu Y. ^{[1
]}

Du W. ^{[2
]}

Hu Q. ^{[1
]}

Su A. ^{[1
]}

Xu H. ^{[1
]}

Liu J. ^{[1
]}

Xie M. ^{[1
]}

Yang W. ^{[1
]}

机构：

[1] Collaborative Innovation Center for Modern Grain Circulation and Safety, Key Laboratory of Grains and Oils Quality Control and Processing, College of Food Science and Engineering, Nanjing University of Finance and Economics, Nanjing

[2] Nanjing Foreign Language School, Nanjing

来源：

Shipin Kexue/Food Science | 2021年 / 42卷 / 21期

关键词：

Anti-inflammatory; Antioxidant; Antitumor; Hericium erinaceus; Peptides;

D O I：

10.7506/spkx1002-6630-20210104-035

中图分类号：

学科分类号：

摘要：

In this study, papain, flavourzyme, alcalase and trypsin were separately used to hydrolyze Hericium erinaceus proteins, yielding peptides designated as HEPH-P, HEPH-F, HEPH-A, and HEPH-T, respectively. Their antioxidant, antiinflammatory activity, and antitumor activities were evaluated. The results showed that HEPH-P had good 2, 2-di(4-tertoctylphenyl)-1-picrylhydrazyl (DPPH) radical and hydroxyl radical-scavenging activities, with scavenging percentages of(53.01 ± 0.27)% and (55.73 ± 1.52)%, respectively. HEPH-A showed anti-inflammatory activity by effectively controlling the release of NO and interleukin (IL)-6 and promoting the secretion of IL-10 in lipopolysaccharide (LPS)-induced RAW264.7 cells. HEPH-P resulted in the rupturing of the cell membrane, triggered apoptosis and ultimately inhibited the proliferation of liver cancer cells. This study can provide a theoretical basis for the development and application of functionally active peptides from Hericium erinaceus proteins. © 2021, China Food Publishing Company. All right reserved.

引用

页码：119 / 127

页数：8

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