Agent-based modeling for the tumor microenvironment (TME)

被引：0

作者：

Weerasinghe, Hasitha N. ^{[1
]}

Burrage, Pamela M. ^{[1
]}

Nicolau, Dan V. ^{[2
]}

Burrage, Kevin ^{[1
,3
]}

机构：

[1] School of Mathematical Sciences, Queensland University of Technology, Brisbane, QLD

[2] School of Immunology and Microbial Sciences, Kings College, London

[3] Department of Computer Science, University of Oxford

来源：

Mathematical Biosciences and Engineering | 2024年 / 21卷 / 11期

基金：

澳大利亚研究理事会;

关键词：

agent-based modeling; cancer; invasion; plasticity; tumor microenvironment;

D O I：

10.3934/mbe.2024335

中图分类号：

学科分类号：

摘要：

Cancer is a disease that arises from the uncontrolled growth of abnormal (tumor) cells in an organ and their subsequent spread into other parts of the body. If tumor cells spread to surrounding tissues or other organs, then the disease is life-threatening due to limited treatment options. This work applies an agent-based model to investigate the effect of intra-tumoral communication on tumor progression, plasticity, and invasion, with results suggesting that cell-cell and cell-extracellular matrix (ECM) interactions affect tumor cell behavior. Additionally, the model suggests that low initial healthy cell densities and ECM protein densities promote tumor progression, cell motility, and invasion. Furthermore, high ECM breakdown probabilities of tumor cells promote tumor invasion. Understanding the intra-tumoral communication under cellular stress can potentially lead to the design of successful treatment strategies for cancer. © 2024 the Author(s), licensee AIMS Press.

引用

页码：7621 / 7647

页数：26

共 100 条

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