Metal-phenolic network composites: from fundamentals to applications

Composites with tailored compositions and functions have attracted widespread scientific and industrial interest. Metal-phenolic networks (MPNs), which are composed of phenolic ligands and metal ions, are amorphous adhesive coordination polymers that have been combined with various functional components to create composites with potential in chemistry, biology, and materials science. This review aims to provide a comprehensive summary of both fundamental knowledge and advancements in the field of MPN composites. The advantages of amorphous MPNs, over crystalline metal-organic frameworks, for fabricating composites are highlighted, including their mild synthesis, diverse interactions, and numerous intrinsic functionalities. The formation mechanisms and state-of-the-art synthesis strategies of MPN composites are summarized to guide their rational design. Subsequently, a detailed overview of the chemical interactions and structure-property relationships of composites based on different functional components (e.g., small molecules, polymers, biomacromolecules) is provided. Finally, perspectives are offered on the current challenges and future directions of MPN composites. This tutorial review is expected to serve as a fundamental guide for researchers in the field of metal-organic materials and to provide insights and avenues to enhance the performance of existing functional materials in applications across diverse fields. This review provides a guideline for the rational design of metal-phenolic network (MPN) composites-which are fabricated from MPN and one or more functional components (e.g., drugs, proteins)-for various applications across diverse disciplines.