A brief review of molecular information theory

被引：54
作者：
Schneider T.D. [1 ]
机构：
[1] National Institutes of Health, National Cancer Institute at Frederick, MD 21702-1201, P.O. Box B, Frederick
来源：
Nano Communication Networks | 2010年 / 1卷 / 03期
基金：
美国国家卫生研究院;
关键词：
Channel capacity; Information theory; Molecular efficiency; Nanotechnology; Sequence logo; Sequence walker;
D O I：
10.1016/j.nancom.2010.09.002
中图分类号：
学科分类号：
摘要：
The idea that we could build molecular communications systems can be advanced by investigating how actual molecules from living organisms function. Information theory provides tools for such an investigation. This review describes how we can compute the average information in the DNA binding sites of any genetic control protein and how this can be extended to analyze its individual sites. A formula equivalent to Claude Shannon's channel capacity can be applied to molecular systems and used to compute the efficiency of protein binding. This efficiency is often 70% and a brief explanation for that is given. The results imply that biological systems have evolved to function at channel capacity, which means that we should be able to build molecular communications that are just as robust as our macroscopic ones. © 2010.
引用
收藏
页码：173 / 180
页数：7
相关论文
共 71 条
[51]  
Schneider T.D., Rogan P.K., (1999)
[52]  
Schneider T.D., Stephens R.M., Sequence logos: a new way to display consensus sequences, Nucleic Acids Res., 18, pp. 6097-6100, (1990)
[53]  
Schneider T.D., Stormo G.D., Excess information at bacteriophage T7 genomic promoters detected by a random cloning technique, Nucleic Acids Res., 17, pp. 659-674, (1989)
[54]  
Schneider T.D., Stormo G.D., Gold L., Ehrenfeucht A., Information content of binding sites on nucleotide sequences, J. Mol. Biol., 188, pp. 415-431, (1986)
[55]  
Shannon C.E., A mathematical theory of communication, Bell Syst. Tech. J., 27, pp. 379-423, (1948)
[56]  
Shannon C.E., Communication in the presence of noise, Proc. IRE, 37, pp. 10-21, (1949)
[57]  
Shannon C.E., Weaver W., The Mathematical Theory of Communication, (1949)
[58]  
Shultzaberger R.K., Bucheimer R.E., Rudd K.E., Schneider T.D., Anatomy of Escherichia coli ribosome binding sites, J. Mol. Biol., 313, pp. 215-228, (2001)
[59]  
Shultzaberger R.K., Chen Z., Lewis K.A., Schneider T.D., Anatomy of Escherichia coli~70 promoters, Nucleic Acids Res., 35, pp. 771-788, (2007)
[60]  
Shultzaberger R.K., Roberts L.R., Lyakhov I.G., Sidorov I.A., Stephen A.G., Fisher R.J., Schneider T.D., Correlation between binding rate constants and individual information of E. coli Fis binding sites, Nucleic Acids Res., 35, pp. 5275-5283, (2007)
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