Synthesis of nitric oxide-releasing silica nanoparticles

被引：0

作者：

Jae, Ho Shin ^{[1
]}

Metzger, Sara K. ^{[1
]}

Schoenfisch, Mark H. ^{[1
]}

机构：

[1] Department of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, United States

来源：

Journal of the American Chemical Society | 2007年 / 129卷 / 15期

关键词：

The synthesis and characterization of a new nitric oxide (NO)-releasing scaffold prepared from amine-functionalized silica nanoparticles are reported. Inorganic-organic hybrid silica was prepared via cocondensation of tetraethoxy- or tetramethoxysilane (TEOS or TMOS) and aminoalkoxysilane with appropriate amounts of ethanol (or methanol); water; and ammonia. The amine functional groups in the silica were converted to N-diazeniumdiolate NO donors via exposure to high pressures of NO (5 atm) under basic conditions. Control over both the structure and concentration of the silane precursors (i.e; tetraalkoxy- and aminoalkoxysilanes) and specific synthetic conditions allowed for the preparation of NO donor silica particles of widely varying sizes (d = 20-500 nm); NO payloads (50-1780 nmol&middotmg-1); maximum amounts of NO released (10-5500 ppb&middotmg-1); half-lives; (0.1-12; h); and NO release durations (up to 30 h). The silica nanoparticles were characterized by solid-state 29Si nuclear magnetic resonance (NMR); atomic force microscopy (AFM); elemental analysis; and gas adsorption-desorption isotherms. The advantages of silica-derived NO storage/delivery systems over previously reported macromolecular NO donors include the ability to (1) store large quantities of NO; (2) modulate NO release kinetics; and (3) readily tune particle size based on the composition of the particle. In addition; a one-pot strategy for preparing the NO donor silica allows for straightforward; high-throughput synthesis and purification. © 2007 American Chemical Society;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Journal article (JA)

引用

页码：4612 / 4619

共 50 条

[21] Biotemplated Synthesis and Characterization of Mesoporous Nitric Oxide-Releasing Diatomaceous Earth Silica Particles
Grommersch, Bryan M.
Pant, Jitendra
Hopkins, Sean P.
Goudie, Marcus J.
Handa, Hitesh
ACS APPLIED MATERIALS & INTERFACES, 2018, 10 (03) : 2291 - 2301
[22] Stober Synthesis of Nitric Oxide-Releasing S-Nitrosothiol-Modified Silica Particles
Riccio, Daniel A.
Nugent, Julia L.
Schoenfisch, Mark H.
CHEMISTRY OF MATERIALS, 2011, 23 (07) : 1727 - 1735
[23] Size and shape dependent anti-biofilm efficacy of nitric oxide-releasing silica nanoparticles
Slomberg, Danielle L.
Lu, Yuan
Carpenter, Alexis W.
Schoenfisch, Mark H.
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2012, 244
[24] Nitric oxide-releasing S-nitrosothiol-modified silica/chitosan core shell nanoparticles
Chang, Wei-Lin
Peng, Kang-Jen
Hu, Teh-Min
Chiu, Shih-Jiuan
Liu, Ying-Ling
POLYMER, 2015, 57 : 70 - 76
[25] PMSE 382-Nitric oxide-releasing silica nanoparticles: Synthesis, characterization, and efficacy against ovarian cancer cells
Li, Bing
Li, Lingyu
Stewart, Molly A.
Li, Christopher
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2006, 232 : 291 - 291
[26] Nitric Oxide-Releasing Cyclodextrins
Jin, Haibao
Yang, Lei
Ahonen, Mona Jasmine R.
Schoenfisch, Mark H.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2018, 140 (43) : 14178 - 14184
[27] Nitric oxide-releasing drugs
Napoli, C
Ignarro, LJ
ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, 2003, 43 : 97 - 123
[28] Synthesis and characterization of nitric oxide-releasing biodegradable polyesters
Coneski, Peter N.
Schoenfisch, Mark H.
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2009, 237
[29] Nitric Oxide-Releasing Alginates
Ahonen, Mona Jasmine R.
Suchyta, Dakota J.
Zhu, Huanyu
Schoenfisch, Mark H.
BIOMACROMOLECULES, 2018, 19 (04) : 1189 - 1197
[30] Antibacterial properties of nitric oxide-releasing porous silicon nanoparticles
Kafshgari, M. Hasanzadeh
Delalat, B.
Harding, F. J.
Cavallaro, A.
Makila, E.
Salonen, J.
Vasilev, K.
Voelcker, N. H.
JOURNAL OF MATERIALS CHEMISTRY B, 2016, 4 (11) : 2051 - 2058

← 1 2 3 4 5 →