Synthesis of nitric oxide-releasing silica nanoparticles

被引：0
|
作者：
Jae, Ho Shin [1 ]
Metzger, Sara K. [1 ]
Schoenfisch, Mark H. [1 ]
机构：
[1] Department of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, United States
来源：
Journal of the American Chemical Society | 2007年 / 129卷 / 15期
关键词：
The synthesis and characterization of a new nitric oxide (NO)-releasing scaffold prepared from amine-functionalized silica nanoparticles are reported. Inorganic-organic hybrid silica was prepared via cocondensation of tetraethoxy- or tetramethoxysilane (TEOS or TMOS) and aminoalkoxysilane with appropriate amounts of ethanol (or methanol); water; and ammonia. The amine functional groups in the silica were converted to N-diazeniumdiolate NO donors via exposure to high pressures of NO (5 atm) under basic conditions. Control over both the structure and concentration of the silane precursors (i.e; tetraalkoxy- and aminoalkoxysilanes) and specific synthetic conditions allowed for the preparation of NO donor silica particles of widely varying sizes (d = 20-500 nm); NO payloads (50-1780 nmol&middotmg-1); maximum amounts of NO released (10-5500 ppb&middotmg-1); half-lives; (0.1-12; h); and NO release durations (up to 30 h). The silica nanoparticles were characterized by solid-state 29Si nuclear magnetic resonance (NMR); atomic force microscopy (AFM); elemental analysis; and gas adsorption-desorption isotherms. The advantages of silica-derived NO storage/delivery systems over previously reported macromolecular NO donors include the ability to (1) store large quantities of NO; (2) modulate NO release kinetics; and (3) readily tune particle size based on the composition of the particle. In addition; a one-pot strategy for preparing the NO donor silica allows for straightforward; high-throughput synthesis and purification. © 2007 American Chemical Society;
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Journal article (JA)
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页码：4612 / 4619
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