Fabrication of a controlled-release delivery system for pesticides using carbon dioxide-based copolymer microcapsules

被引：0
|
作者：
Li, Hongchun [1 ]
Xu, Jie [1 ]
Niu, Yongsheng [1 ]
机构：
[1] Qingdao Agr Univ, Coll Chem & Pharm, Qingdao 266109, Peoples R China
来源：
MATERIALS TODAY CHEMISTRY | 2025年 / 43卷
基金：
中国国家自然科学基金;
关键词：
Carbon dioxide; Amphiphilic graft copolymer; pH-responsiveness; Nanoparticle; Pesticide delivery; STIMULI-RESPONSIVE POLYMERS; DRUG-DELIVERY; MICELLES; NANOPARTICLES; CHITOSAN; SHELL; POLYMERIZATION; ENCAPSULATION; STABILITY; CORE;
D O I：
10.1016/j.mtchem.2024.102460
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The pH-responsive pesticide delivery system can enhance utilization efficiency of pesticides and reduce environmental pollution. Herein, an environmental and amphiphilic carbon dioxide-based copolymer, poly(propylene oxide-co-carbon dioxide-co-allyl glycidyl ether)-poly(polyacrylic acid)-methoxy poly(ethylene glycol) (PPAG-PAA-mPEG), was synthesized to fabricate a pH-responsive pesticide delivery system. The avermectin (AVE) was selected as a model drug to show PPAG-PAA-mPEG potential as a controlled-release pesticide system. The entrapment efficiency and the loading content of the AVE-loaded micelles was 88.6 % and 36.98 %, respectively. The AVE-loaded micelles were stable. The release rate of AVE gradually increased with the increase of pH. Pot trial showed that the AVE-loaded micelles showed a good pesticidal efficacy. Because of CO2 as raw materials, and excellent pH-responsive controlled-release performance, these on-demand pesticide delivery systems might have significant potential in improving the utilization efficiency of pesticides in modern agriculture.
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页数：13
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