Characterization of cytochalasins from the endophytic Xylaria sp. and their biological functions

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机构：

[1] Zhang, Qiang

[2] 1,Xiao, Jian

[3] Sun, Qing-Qing

[4] Qin, Jian-Chun

[5] Pescitelli, Gennaro

[6] Gao, Jin-Ming

来源：

Gao, Jin-Ming | 1600年 / American Chemical Society卷 / 62期

关键词：

Bioassay-guided fractionation of the fermentation extract of Xylaria sp. XC-16; an endophyte from Toona sinensis led to the isolation of two new cytochalasans cytochalasin Z27; 1; and cytochalasin Z28; 2; along with three known compounds seco-cytochalasin E; 3; and cytochalasin Z18; 4; and cytochalasin E; 5. The structures of 1 and 2 were elucidated by spectroscopic and electronic circular dichroism methods. Compound 5 was shown to be potently cytotoxic against brine shrimp (LC50 = 2.79 μM); comparable to that of the positive agent toosendanin (LC50 = 4.03 μM); and also exhibited potential phytotoxic effects on Lactuca sativa and Raphanus sativus L. seedlings; which are higher than that of the positive control glyphosate. Additionally; the fungicidal effect of 2 against the phytopathogen Gibberella saubinetti was better than that of hymexazol. This is the first report of the three types of cytochalasins present in genus Xylaria. A structure-phytotoxicity activity relationship is also discussed. © 2014 American Chemical Society;

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Journal article (JA)

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