Microbubble compositions, properties and biomedical applications

被引：447
作者：
Department of Chemical Engineering, Columbia University, 500 W 120 Street, New York, NY 10027, United States [1 ]
机构：
[1] Department of Chemical Engineering, Columbia University, New York, NY 10027
来源：
Bubble Sci. Eng. Technol. | 2009年 / 1-2卷 / 3-17期
关键词：
Colloidal bubbles; Gas filled microparticles; Hollow microspheres; Spherical foams; Targeted drug and gene delivery; Ultrasound molecular imaging;
D O I：
10.1179/175889709X446507
中图分类号：
学科分类号：
摘要：
Over the last decade, there has been a significant progress towards the development of microbubbles as theranostics for a wide variety of biomedical applications. The unique ability of microbubbles to respond to ultrasound makes them useful agents for contrast ultrasound imaging, molecular imaging, and targeted drug and gene delivery. The general composition of a microbubble is a gas core stabilised by a shell comprised of proteins, lipids or polymers. Each type of microbubble has its own unique advantages and can be tailored for specialised functions. In this review, different microbubbles compositions and physiochemical properties are discussed in the context of current progress towards developing novel constructs for biomedical applications, with specific emphasis on molecular imaging and targeted drug/gene delivery. © 2009 Institute of Materials, Minerals and Mining.
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页码：3 / 17
页数：14
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