CuS@Ag Heterostructure-based Surface Plasmonic Coupling Electrochemiluminescence Sensor for Glioma miRNA-124-3p Detection

被引：3

作者：

Li, Wenyan ^{[1
]}

Liang, Zihui ^{[1
]}

Wang, Peilin ^{[1
]}

Li, Zhenrun ^{[1
]}

Ma, Qiang ^{[1
]}

机构：

[1] Jilin Univ, Coll Chem, Dept Analyt Chem, Changchun 130012, Peoples R China

来源：

BIOSENSORS & BIOELECTRONICS | 2025年 / 274卷

基金：

中国国家自然科学基金;

关键词：

Aggregation-induced; electrochemiluminescence; Covalent organic frameworks; Surface plasmonic coupling effect; miRNA-124-3p detection; Glioma diagnosis; FRAMEWORK; THERAPY;

D O I：

10.1016/j.bios.2025.117202

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

As an emerging class of extended crystalline organic materials, covalent organic framework (COF)-based aggregation-induced emission luminogen (AIE-gen) exhibited encouraging emissive properties. In this work, 4',4",4 & tprime;,4 & tprime;'-(1,1,2,2-Ethenetetrayl)tetra(4-biphenylcarbaldehyde) (ETBC) as AIEgen was used to prepare AIECOF (ET-COF-COOH) luminescent nanoprobe. ETBC and 1,3,5-Tris(4-aminophenyl)benzene (TAPB) had an extended it electronic system that allowed electron delocalization and overlapping transport. Because AIEgenETBC served as the luminescence center of ET-COF-COOH, the ET-COF-COOH possessed an ideal anodic electrochemiluminescence (ECL) performance. Moreover, due to the surface plasmonic coupling (SPC) effect of the CuS@Ag square-cavity array, the ECL signal of ET-COF-COOH was amplified as 2.8 times. The AIE-COF/CuS@Ag SCH array-based SPC-ECL sensor was used to detect miRNA-124-3p with a wide range of 1 fM-10 nM and LOD of 0.49 fM. Furthermore, the proposed biosensor can effectively distinguish between tumor tissue and adjacent tissue and offer significant potential for advancing glioma diagnosis.

引用

页数：8