Modeling the Kinetics of Drug Desorption from a Tablet Based on a Polymer Matrix

被引：0

作者：

Chernousova, N.V. ^{[1
]}

Zakharova, V.A. ^{[1
]}

Dedov, A.V. ^{[2
]}

机构：

[1] Kosygin Russian State University (Technology. Design. Art), Moscow

[2] Moscow Polytechnic University, Moscow

来源：

Polymer Science - Series D | 2024年 / 17卷 / 03期

关键词：

desorption; medicine; mixing; model; tablet;

D O I：

10.1134/S1995421224701144

中图分类号：

学科分类号：

摘要：

Abstract: Using literature data, a model was developed to predict the kinetics of drug’ desorption from hydroxypropyl-methylcellulose-based tablets at different water stirring rates. When the tablet comes into contact with a gastric juice, the polymer swells to form a gel-like shell, which prevents the transfer of gastric juice into the tablet and determines the rate of drug release into the human body. We used an equation that describes the kinetic dependences of drug desorption in the coordinate system of a conditional time equal to the square root of the observation time. Dependence of the equation coefficients on the stirring speed was established, which made it possible to obtain a model for predicting the kinetics of drug desorption from the time of contact with water and the water stirring speed. © Pleiades Publishing, Ltd. 2024. ISSN 1995-4212, Polymer Science, Series D, 2024, Vol. 17, No. 3, pp. 670–673. Pleiades Publishing, Ltd., 2024. Russian Text The Author(s), 2024, published in Vse Materialy, 2024, No. 1, pp. 26–30.

引用

页码：670 / 673

页数：3

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