Modification of fluorophore photophysics through peptide-driven self-assembly

被引：0
|
作者：
Channon, Kevin J. [1 ]
Devlin, Glyn L. [2 ]
Magennis, Steven W. [3 ]
Finlayson, Chris E. [1 ]
Tickler, Anna K. [1 ]
Silva, Carlos [4 ]
MacPhee, Cait E. [3 ]
机构：
[1] Cavendish Laboratory, University of Cambridge, JJ Thomson Avenue, Cambridge, CB3 0HE, United Kingdom
[2] Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, United Kingdom
[3] SUPA, School of Physics, University of Edinburgh, Mayfield Road, Edinburgh, EH9 3JZ, United Kingdom
[4] Départment de Physique, Université de Montréal, succ. centre-ville, Montréal, QC H3C 3J7, Canada
来源：
Journal of the American Chemical Society | 2008年 / 130卷 / 16期
关键词：
We describe the formation of self-assembling nanoscale fibrillar aggregates from a hybrid system comprising a short polypeptide conjugated to the fluorophore fluorene. The fibrils are typically unbranched; ∼7 nm in diameter; and many microns in length. A range of techniques are used to demonstrate that the spectroscopic nature of the fluorophore is significantly altered in the fibrillar environment. Time-resolved fluorescence spectroscopy reveals changes in the guest fluorophore; consistent with energy migration and excimer formation within the fibrils. We thus demonstrate the use of self-assembling peptides to drive the assembly of a guest moiety; in which novel characteristics are observed as a consequence. We suggest that this method could be used to drive the assembly of a wide range of guests; offering the development of a variety of useful; smart nanomaterials that are able to self-assemble in a controllable and robust fashion. © 2008 American Chemical Society;
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页码：5487 / 5491
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