Effects of cholesterol/lecithin on the microscopic structure of hydroxyapatite in chitosan substrate

Chitosan/hydroxyapatite composite materials were prepared, the influence of synergistic action of cholesterol and lecithin on the microscopic structure of hydroxyapatite in the chitosan substrate was investigated. The results show: for the composite materials with different proportions of cholesterol and lecithin the microscopic structure of hydroxyapatite changed from the spherical to the claviform. When the proportion of lecithin and cholesterol is 5: 1, the microscopic structure and size of hydroxyapatite in composite materials is closed to nature bone tissue. But in the control system without lecithin and cholesterol, the microscopic structures of hydroxyapatite are amorphous lamellate almostly. The cholesterol and lecithin can affect the microscopic structure of hydroxyapatite. Addition the difference proportions of lecithin and cholesterol in composite materials system were benefited of formation of hydroxyapatite production of differences microscopic structure. © Copy Right.