Applications of PLA in modern medicine

被引：390
作者：
DeStefano V. [1 ]
Khan S. [1 ]
Tabada A. [1 ]
机构：
[1] Department of Biomedical Engineering, Stony Brook University, Stony Brook, 11794, NY
来源：
Engineered Regeneration | 2020年 / 1卷
关键词：
Cancer therapy; Cardiovascular; Dental; Drug carriers; Orthopedics; Polylactic acid; Polymers; skin/tendon healing; surgical tools; Tissue engineering;
D O I：
10.1016/j.engreg.2020.08.002
中图分类号：
学科分类号：
摘要：
Polylactic acid (PLA) is a versatile biopolymer. PLA is synthesized with ease from abundant renewable resources and is biodegradable. PLA has shown promise as a biomaterial in a plethora of healthcare applications such as tissue engineering or regenerative medicine, cardiovascular implants, dental niches, drug carriers, orthopedic interventions, cancer therapy, skin and tendon healing, and lastly medical tools / equipment. PLA has demonstrated instrumental importance as a three-dimensionally (3D) printable biopolymer, which has further been bolstered by its role during the Coronavirus Disease of 2019 (Covid-19) global pandemic. As an abundant filament, PLA has created desperately needed personal protective equipment (PPE) and ventilator modifications. As polymer chemistry continues to advance, so too will the applications and continued efficacy of PLA-based modalities. © 2020 KeAi Communications Co., Ltd
引用
收藏
页码：76 / 87
页数：11
相关论文
共 60 条
[1]  
Market Study: Bioplastics (4th Edition), (2016)
[2]  
Jamshidian M., Tehrany E.A., Imran M., Jacquot M., Desobry S., Poly-lactic acid: production, applications, nanocomposites, and release studies, Comprehens. Rev. Food Sci. Food Saf., 9, 5, pp. 552-571, (2010)
[3]  
Farah S., Anderson D.G., Langer R., Physical and mechanical properties of PLA, and their functions in widespread applications — a comprehensive review, Adv. Drug Deliv. Rev., 107, pp. 367-392, (2016)
[4]  
Perego G., Cella G.D., Bastioli C., Effect of molecular weight and crystallinity on poly(lactic acid) mechanical properties, J. Appl. Polym. Sci., 59, 1, pp. 37-43, (1996)
[5]  
Hartmann M.H., High molecular weight polylactic acid polymers, Biopolymers from Renewable Resources, pp. 367-411, (1998)
[6]  
Sodergard A., Stolt M., Properties of lactic acid based polymers and their correlation with composition, Progr. Polym. Sci., 27, 6, pp. 1123-1163, (2002)
[7]  
Rasal R.M., Janorkar A.V., Hirt D.E., Poly(lactic acid) modifications, Progr. Polym. Sci., 35, 3, pp. 338-356, (2010)
[8]  
Casalini T., Rossi F., Castrovinci A., Perale G., A perspective on polylactic acid-based polymers use for nanoparticles synthesis and applications, Front. Bioeng. Biotechnol., 7, 259, (2019)
[9]  
Gardella L., Calabrese M., Monticelli O., PLA maleation: an easy and effective method to modify the properties of PLA/PCL immiscible blends, Colloid Polym. Sci., 292, 9, pp. 2391-2398, (2014)
[10]  
Shin B.Y., Han D.H., Compatibilization of immiscible poly(lactic acid)/poly(ε-caprolactone) blend through electron-beam irradiation with the addition of a compatibilizing agent, Radiat. Phys. Chem., 83, pp. 98-104, (2013)
123456