Comparison of modified airlift reactor with conventional airlift reactor

被引：0

作者：

Ghosh, T.K. ^{[1
]}

Banerjee, Shounak ^{[1
]}

Majumder, C.B. ^{[2
]}

Kim, Tai-Hoon ^{[3
]}

机构：

[1] Department of Biotechnology, Heritage Institute of Technology, Kolkata -700107, India

[2] Department of Chemical Engineering, Indian Institute of Technology, Roorkee - 247-667, India

[3] Hannam University, Daejeon, Korea, Republic of

来源：

International Journal of Control and Automation | 2010年 / 3卷 / 03期

关键词：

Fermenters - Growth rate - Animal cell culture - Geometry;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Air supply is a crucial parameter for many aerobic processes. Specific growth rate (μ) was determined for both the reactors (conventional UT-ALF and modified CDT-ALF) under identical operating conditions. The conventional uniform tube external loop airlift fermenter (UT-ALF) was modified keeping the volume and height same. Only the riser part of the conventional external loop airlift fermenter was replaced by a irregular geometry in the form of converging-diverging tube. The modified system is thus named converging-diverging tube airlift fermenter (CDT-ALF), which possesses a novel geometry comprised of walls with sinusoidal waves that mimic baffles in an effort to promote mixing at low Reynold's number (Re). This geometry provides a unique hydrodynamic environment suitable also for the cultivation of mammalian cells and tissues. The results from UT-ALF and CDT-ALF were compared. At any operating condition CDTALF showed higher μmax (maximum specific growth rate) compared to UT-ALF. The highest (μmax) was observed for CDT-ALF corresponding to an initial sugar concentration of 50 kg/m3 and air flow rate of 1.0 vvm. This was 29 % higher compared to UT-ALF under identical operating conditions. So, operating cost may be minimized to a great extent if commercialized.

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