A 90 Day Safety Assessment of Genetically Modified Rice Expressing Cry1Ab/1Ac Protein using an Aquatic Animal Model

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[1] [1,Zhu, Hao-Jun
[2] Chen, Yi
[3] Li, Yun-He
[4] 1,Wang, Jia-Mei
[5] Ding, Jia-Tong
[6] Chen, Xiu-Ping
[7] Peng, Yu-Fa
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Chen, Xiu-Ping | 1600年 / American Chemical Society卷 / 63期
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In fields of transgenic Bt rice; frogs are exposed to Bt proteins through consumption of both target and nontarget insects. In the present study; we assessed the risk posed by transgenic rice expressing a Cry1Ab/1Ac fusion protein (Huahui 1; HH1) on the development of Xenopus laevis. For 90 days; froglets were fed a diet with 30% HH1 rice; 30% parental rice (Minghui 63; MH63); or no rice as a control. Body weight and length were measured every 15 days. After sacrificing the froglets; we performed a range of biological; clinical; and pathological assessments. No significant differences were found in body weight (on day 90: 27.7 ± 2.17; 27.4; ±; 2.40; and 27.9 ± 1.67 g for HH1; MH63; and control; respectively); body length (on day 90: 60.2 ± 1.55; 59.3; 2.33; and 59.7 ± 1.64 mm for HH1; animal behavior; organ weight; liver and kidney function; or the microstructure of some tissues between the froglets fed on the HH1-containing diet and those fed on the MH63-containing or control diets. This indicates that frog development was not adversely affected by dietary intake of Cry1Ab/1Ac protein. © 2015 American Chemical Society;
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