Adipose-derived adult stem cells: Available technologies for potential clinical regenerative applications in dentistry

被引：0

作者：

Catalano, Enrico ^{[1
,2
]}

Cochis, Andrea ^{[1
,2
]}

Varoni, Elena ^{[1
,2
]}

Rimondini, Lia ^{[1
,2
]}

Carrassi, Antonio ^{[3
]}

Azzimonti, Barbara ^{[2
,4
]}

机构：

[1] Laboratory of Biomedical and Dental Materials, Department of Health Sciences, Università del Piemonte Orientale 'A. Avogadro', 28100 Novara (NO)

[2] Consorzio Interuniversitario Nazionale per la Scienza e Tecnologia dei Materiali (INSTM), 50121 Florence (FI)

[3] Department of Biomedical, Surgical and Odontoiatric Sciences, Università degli Studi di Milano, 20122 Milan (MI)

[4] Laboratory of Microbiology, Department of Health Sciences, Università del Piemonte Orientale 'A. Avogadro', 28100 Novara (NO)

来源：

Critical Reviews in Biomedical Engineering | 2014年 / 41卷 / 06期

关键词：

Adipose-derived adult stem cells; Biomaterials; Bone; Dental tissue regeneration; Dentistry;

D O I：

10.1615/critrevbiomedeng.2014010683

中图分类号：

学科分类号：

摘要：

Tissue homeostasis depends closely on the activity and welfare of adult stem cells. These cells represent a promising tool for biomedical research since they can aid in treatment and promote the regeneration of damaged organs in many human disorders. Adult stem cells indefinitely preserve their ability to self-renew and differentiate into various phenotypes; this capacity could be promoted in vitro by particular culture conditions (differentiation media) or spontaneously induced in vivo by exploiting the biochemical and mechanical properties of the tissue in which the stem cells are implanted. Among the different sources of adult stem cells, adipose tissue is an attractive possibility thanks to its ready availability and the standard extraction techniques at our disposal today. This review discusses the isolation, characterization, and differentiation of human adipose-derived adult stem cells, as well as regeneration strategies, therapeutic uses, and adverse effects of their delivery. In particular, since oral disorders (e.g., trauma, erosion, and chronic periodontitis) often cause the loss of dental tissue along with functional, phonetic, and aesthetic impairment, this review focuses on the application of human adipose-derived adult stem cells, alone or in combination with biomaterials, in treating oral diseases. © 2013 by Begell House, Inc.

引用

页码：483 / 493

页数：10

共 60 条

[1]

Backsh D., Song L., Tuan R.S., Adult mesenchymal stem cells: Characterization, differentiation and applications in cell and gene therapy, J Cell Mol Med, 8, pp. 301-316, (2004)

[2]

Gimble J.M., Katz A.J., Bunnel B.A., Adipose derived stem cells for regenerative medicine, Circ Res, 100, pp. 1249-1260, (2007)

[3]

Inanc B., Elcin A.E., Unsal E., Balos K., Parlar A., Elcin Y.M., Differentiation of human embryonic stem cells on periodontal ligament fibroblasts in vitro, Artif Organs, 22, pp. 100-109, (2008)

[4]

Seo B.M., Miura M., Gronthos S., Bartold P.M., Batouli S., Brahim J., Young M., Robey P.G., Wang C.Y., Shi S., Investigation of multipotent postnatal stem cells from human periodontal ligament, Lancet, 364, 9429, pp. 149-155, (2004)

[5]

Fraser J.K., Wulur I., Alfonso Z., Hedrick M.H., Fat tissue: An underappreciate source of stem cells for biotechnology, Trends Biotechnol, 24, pp. 150-154, (2006)

[6]

Guilak F., Lott K.E., Awad H.A., Cao Q., Hicok K.C., Fermor B., Gimble J.M., Clonal analysis of the differentiation potential of human adipose-derived adult stem cells, J Cells Physiol, 206, pp. 229-237, (2006)

[7]

Helder M.N., Knippenberg M., Klein-Nulend J., Wuisman P.I., Stem cells from adipose tissue allow challenging new concepts for regenerative medicine, Tissue Eng, 13, pp. 1799-1808, (2007)

[8]

Mizuno H., Zuk P.A., Zhu M., Lorenz H.P., Benhaim P., Hedrick M.H., Myogenic differentiation by human processed lipoaspirate cells, Plast Reconstr Surg, 109, pp. 199-211, (2002)

[9]

Zuk P.A., Zhu M., Mizuno H., Huang J., Futrell J.W., Katz A.J., Benhaim P., Lorenz H.P., Hedrick M.H., Multilineage cells from human adipose tissue: Implications for cell-based therapies, Tissue Eng, 7, pp. 211-228, (2001)

[10]

Tobita M., Uysal A.C., Ogawa R., Hyakusoku H., Mizuno H., Periodontal tissue regeneration with adipose-derived stem cells, Tissue Eng Part A, 14, 6, pp. 945-953, (2008)

← 1 2 3 4 5 6 →