Blood compatibility of titanium oxide powder after high temperature annealing

被引：0

作者：

Zhao, Ansha ^{[1
]}

Wang, Zhao ^{[1
]}

Zhou, Shuo ^{[1
]}

Zhu, Xiaohua ^{[1
]}

Xie, Xiao ^{[2
]}

Huang, Nan ^{[1
]}

机构：

[1] Key Laboratory of Advanced Materials Technology of Ministry of Education, Southwest Jiaotong University

[2] State Key Laboratory of Bioelectronics, Southeast University

来源：

Xinan Jiaotong Daxue Xuebao/Journal of Southwest Jiaotong University | 2014年 / 49卷 / 02期

关键词：

Annealing; Blood compatibility; Interface; Protein; Titanium oxide;

D O I：

10.3969/j.issn.0258-2724.2014.02.027

中图分类号：

学科分类号：

摘要：

Vacuum annealing was used to prepare the Ti-O powder at different annealing temperatures. The structure and surface properties were characterized by X-ray diffraction, Zeta potential test and surface area measurement respectively. Bradford method was applied to determine the adsorption and desorption of fibrinogen on the powder, and Fourier transform infrared spectroscopy was used to analyze the change of secondary structure of adsorbed fibrinogen on the samples. Then flow cytometry was used to measure the degree of platelets activation. The results show that after 800°C annealing process, the crystal structure of Ti-O powder transformed from anatase to rutile with 10 times less total surface area and more negative charges, and the amount of fibrinogen adsorption was decreased to 67μg and retained its normal conformation. Less platelet was activated by the annealed Ti-O powder, which proves that it has an excellent blood-compatibility.

引用

页码：367 / 372

页数：5

共 16 条

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