Synthesis and antiproliferative activities of 1-substituted-3-(3-chloro-5-methoxyphenyl)-4-pyridinylpyrazole derivatives against melanoma cell line

被引：0
作者：
Choi, Won-Kyoung [1 ]
Oh, Chang-Hyun [1 ]
机构：
[1] Biomaterials Research Center, Korea Institute of Science and Technology
来源：
Bulletin of the Korean Chemical Society | 2009年 / 30卷 / 09期
关键词：
4-Pyridinylpyrazole; A375; Antiproliferative activity; Melanoma;
D O I：
10.5012/bkcs.2009.30.9.2027
中图分类号：
学科分类号：
摘要：
The synthesis of a new series of diarylureas and amides having a 1-substituted-3-(3-chloro-5-methoxyphenyl)-4-pyridinylpyrazole scaffold is reported here. The in vitro antiproliferative activities of these diaryl derivatives against human melanoma cell line A375 were tested and the effect of substituents on the phenyl ring was investigated. Most of the newly synthesized compounds generally showed superior or similiar activity against A375 to Sorafenib. Among these compounds, IId, IIg and IIh showed excellent activity against A375 compared to Sorafenib.
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页码：2027 / 2031
页数：4
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