Evaluation of some adverse effects of the glycoside convicine in Sprague-Dawley rats

被引：2
作者：
Medical Physiology Department, National Research Center, Dokki, Giza, Egypt [1 ]
不详 [2 ]
不详 [3 ]
机构：
[1] Medical Physiology Department, National Research Center, Dokki, Giza
[2] Medical Biochemistry Department, National Research Center, Dokki, Giza
[3] Pharmacology Department, National Research Center, Dokki, Giza
来源：
Toxicol. Environ. Chem. | 2008年 / 3卷 / 415-420期
关键词：
Albino rat; Convicine; Favism; Free radicals; Red blood cells; Toxicity;
D O I：
10.1080/02772240701483855
中图分类号：
学科分类号：
摘要：
Isouramil (IU) is a glycone of the glycoside convicine isolated from faba beans (Vacia faba L.). Convicine produced a hemolytic crisis termed favism especially in patients deficient in glucose-6-phosphate dehydrogenase. In the present study experiments were performed to investigate the effects of covicine on Sprague-Dawley rats. Three groups of albino rats were used including control, the second and third group were given oral dose of convicine (2 mg 100 g b. wt.-1) for 15 and 30 days, respectively. Convicine produced significant decreases in red blood cell counts and hemoglobin content. The serum albumin/globulin ratio was significantly decreased. There were significant increases in serum and liver total protein, serum bilirubin, globulin, and iron levels. Data indicate that convicine produced similar alterations in blood as observed in human metabolic disease (favism). © 2008 Taylor & Francis.
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页码：415 / 420
页数：5
相关论文
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  • [1] Albano E., Tomasi A., Mannuzzu L., Arese P., Detection of a free radical intermediate from divicine of Vicia FABA, Biochemical Pharmacology, 33, pp. 1701-1704, (1984)
  • [2] Al-Buharian A.E., Oluboyede O.A., Determination of serum iron, total iron-binding capacity and serum ferritin in healthy Saudi adults, Annals of Saudi Medicine, 21, pp. 100-103, (2001)
  • [3] Arbid M.S.S., Marquardt R.R., Effects of intraperitoneally injected vicine and convicine on the rat: Induction of favism-like signs, Journal of the Science of Food and Agriculture, 37, pp. 539-547, (1986)
  • [4] Arbid M.S.S., Marquardt R.R., Favism-like effects of divicine and isouramil in the rat: Acute and chronic effects on animal health, mortalities, blood parameters and ability to exchange respiratory gases, Journal of the Science of Food and Agriculture, 43, pp. 75-90, (1988)
  • [5] Armitage P., Statistical methods in medical research, (1971)
  • [6] Belsey M.A., The epidemiology of favism, Bulletin of WHO, 48, pp. 1-13, (1973)
  • [7] DiRosa M., Calignano A., Carnuccio R., Ialent A., Sautchbin L., Multiple control of inflammation by glucocorticoids, Agent Actions, 17, pp. 284-289, (1973)
  • [8] Drabkin D.L., Austin J.H., Spectrophotometric studies: Spectro-photometric constants for common haemoglobin derivatives in human, dog and rabbit blood, Journal of Biological Chemistry, 98, pp. 719-733, (1932)
  • [9] Drupt F., Determination of serum albumin by bromocresol green, Pharmaceutical Biology, 8, pp. 77-99, (1974)
  • [10] Ferrali M., Signorini C., Ciccoli L., Comporti M., Iron release and membrane damage in erythrocytes exposed to oxidizing agents, phenylhydrazine, divicine and isouramil, Biochemical Journal, 285, pp. 295-301, (1992)
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