A cysteine-activated fluorescent H2S donor for visualizing H2S release and alleviating cellular inflammation

被引：0

作者：

Wang, Nianwei

Wang, Xuan

Wang, Jicheng

Ren, Yikun

Hua, Huiming ^{[1
]}

Li, Dahong ^{[1
]}

机构：

[1] Shenyang Pharmaceut Univ, Minist Educ, Key Lab Struct Based Drug Design Discovery, 103 Wenhua Rd, Shenyang 110016, Peoples R China

来源：

CHEMICAL COMMUNICATIONS | 2024年 / 61卷 / 02期

关键词：

HYDROGEN-SULFIDE;

D O I：

10.1039/d4cc04655b

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

We developed Bcy-NCS, a Cys-specific fluorescent H2S donor with a self-immolative spacer, overcoming the issue of multiple fluorophore release seen in traditional ICT-based donors. Bcy-NCS selectively responds to Cys, releases H2S, and enables fluorescence-based monitoring. It also reduces LPS-induced inflammation in RAW 264.7 cells, indicating potential for inflammation treatment.

引用

页码：266 / 269

页数：5

共 50 条

[1] Cysteine-Activated Hydrogen Sulfide (H2S) Donors
Zhao, Yu
Wang, Hua
Xian, Ming
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2011, 133 (01) : 15 - 17
[2] Cysteine-activated hydrogen sulfide (H2S) delivery through caged carbonyl sulfide (COS) donor motifs
Zhao, Yu
Steiger, Andrea K.
Pluth, Michael D.
CHEMICAL COMMUNICATIONS, 2018, 54 (39) : 4951 - 4954
[3] Cysteine-Activated Small-Molecule H2Se Donors Inspired by Synthetic H2S Donors
Kang, Xueying
Huang, Haojie
Jiang, Chenyang
Cheng, Longhuai
Sang, Yueqian
Cai, Xuekang
Dong, Yalun
Sun, Lu
Wen, Xin
Xi, Zhen
Yi, Long
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2022, 144 (09) : 3957 - 3967
[4] An Activatable Near-Infrared Fluorescence Hydrogen Sulfide (H2S) Donor for Imaging H2S Release and Inhibiting Inflammation in Cells
Zhao, Xinyue
Ning, Lulu
Zhou, Xiaoman
Song, Zhihui
Zhang, Jianjian
Guan, Feng
Yang, Xiao-Feng
ANALYTICAL CHEMISTRY, 2021, 93 (11) : 4894 - 4901
[5] Quinoline H2S donor decorated fluorescent carbon dots: visible light responsive H2S nanocarriers
Bera, Manoranjan
Maji, Somnath
Paul, Amrita
Sahoo, Bikash Kumar
Maiti, Tapas Kumar
Singh, N. D. Pradeep
JOURNAL OF MATERIALS CHEMISTRY B, 2020, 8 (05) : 1026 - 1032
[6] PHOTOIONIZATION STUDY OF (H2S)2 AND (H2S)3
PREST, HF
TZENG, WB
BROM, JM
NG, CY
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1983, 105 (26) : 7531 - 7536
[7] H2S Donor and Bone Metabolism
Hao, Yanming
Wang, Hongzhen
Fang, Lingna
Bian, Jinsong
Gao, Yan
Li, Chong
FRONTIERS IN PHARMACOLOGY, 2021, 12
[8] H2S in inflammation: Time for resolution?
Whiteman, Matthew
Perry, Alexis
Wood, Mark E.
NITRIC OXIDE-BIOLOGY AND CHEMISTRY, 2014, 39 : S3 - S3
[9] H2S and Substance P in Inflammation
Bhatia, Madhav
HYDROGEN SULFIDE IN REDOX BIOLOGY, PT B, 2015, 555 : 195 - 205
[10] H2S Activated Drug Release from Protein Cages
Chen, Weijian
Zhang, Yajie
Li, Xiao
Chen, Hong
Sun, Jian
Feng, Fude
ACS APPLIED MATERIALS & INTERFACES, 2017, 9 (39) : 33571 - 33575

← 1 2 3 4 5 →