Microarray and pathway analysis of Differential Gene Expression between two kinds of prostate cancer cell lines sensitive and insensitive to docetaxel

被引：0

作者：

机构：

[1] Department of Microbiology and Immunology, Basic Medical College of Zhengzhou University

[2] Department of Hepatobiliary Surgery, Henan Provincial Cancer Hospital, Zhengzhou

[3] Center of Functional Experiment, Basic Medical College of Zhengzhou University

来源：

Zhu, S. | 1600年 / Asian Network for Scientific Information卷 / 12期

关键词：

Differential gene expression; Docetaxel; Microarray; Prostate cancer;

D O I：

10.3923/itj.2013.8281.8286

中图分类号：

学科分类号：

摘要：

Analyzing Differential Expression Gene (DEG) and identifying candidate gene in prostate cancer cell lines that were resistant to docetaxel, which might be used for the purposes of screening targeted therapy. Gene expression pro?les of the tumors from docetaxel treated mice were performed using Agilent human whole genomic oligonucleotide microarrays. The microarray data were validated and the differential expression genes were analyzed using IPA software. The prostate cancer cell lines PCS and LNCaP were sensitive to docetaxel but VcaP and CWR22 were resistant to docetaxel cell lines. It indicated that some genes up-regulated or down-regulated in docetaxel resistant cell lines may be candidate genes for targeted therapy, after evaluating by Gene Expression Microarray and signal pathway. The significantiy up-regulated genes including Bcl-11 A, EPHA4 and CX3CL1 may be the potential candidates for further investigation in docetaxel-resistant tumor cells. © 2013 Asian Network for Scientific Information.

引用

页码：8281 / 8286

页数：5

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