Electrochemical study on the interaction of sodium cholate with a supported lipid bilayer membrane

被引：0
|
作者：
Wang, Jian-Guo [1 ]
Yang, Wei-Wei [1 ]
Jiang, Li-Li [1 ]
Lu, Hui [1 ]
Sun, Qiao-Hua [1 ]
Ma, Yong [1 ]
Jiang, Yu-Chun [1 ]
Zang, Shu-Liang [1 ]
机构：
[1] College of Chemistry, Liaoning University, Shenyang 110036, China
来源：
Gaodeng Xuexiao Huaxue Xuebao/Chemical Journal of Chinese Universities | 2007年 / 28卷 / 05期
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摘要：
The supported bilayer lipid membrane (s-BLM) was served as a biomembrane model. The interaction between sodium cholate (NaC) and s-BLM was investigated by cyclic voltammetry and alternating current (AC) impedance spectroscopy. The following conclusions were obtained: NaC can decrease the orderliness of lecithin molecule arrangement and induce pores or defects on s-BLM and the interaction between them depends on time, concentration and cholesterol. In addition, the defective s-BLM after interaction can be self-repaired in 0.1 mol/L KC1 solution, which indicates that the interaction is reversible. Moreover, a possible mechanism of the interaction was proposed finally.
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页码：859 / 861
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