Gut commensal bacteria Parabacteroides goldsteinii-derived outer membrane vesicles suppress skin inflammation in psoriasis

被引：1

作者：

Su, Dandan ^{[1
]}

Li, Manchun ^{[1
]}

Xie, Yuedong ^{[1
]}

Xu, Zhanxue ^{[2
]}

Lv, Guowen ^{[3
]}

Jiu, Yaming ^{[4
,5
]}

Lin, Jingxiong ^{[1
]}

Chang, Chih-Jung ^{[6
,7
,8
]}

Chen, Hongbo ^{[1
]}

Cheng, Fang ^{[1
]}

机构：

[1] Sun Yat Sen Univ, Sch Pharmaceut Sci Shenzhen, Shenzhen Campus, Shenzhen 518107, Peoples R China

[2] Sun Yat Sen Univ, Affiliated Hosp 7, Dept Pharm, Shenzhen Key Lab Chinese Med Act Subst Screening &, Shenzhen 518107, Peoples R China

[3] Northwest A&F Univ, Coll Life Sci, Yangling 712100, Peoples R China

[4] Chinese Acad Sci, Shanghai Inst Immun & Infect, Ctr Microbes Dev & Hlth, Key Lab Mol Virol & Immunol,Unit Cell Biol,Imaging, Shanghai 200031, Peoples R China

[5] Univ Chinese Acad Sci, Shijingshan Dist Beijing 100049 China, Yuquan Rd 19 A, Beijing 100049, Peoples R China

[6] Xiamen Chang Gung Hosp, Med Res Ctr, Xiamen 361028, Peoples R China

[7] Xiamen Chang Gung Hosp, Xiamen Chang Gung Allergol Consortium, Xiamen 361028, Peoples R China

[8] Huaqiao Univ, Sch Med, Quanzhou 362021, Peoples R China

来源：

JOURNAL OF CONTROLLED RELEASE | 2025年 / 377卷

基金：

中国国家自然科学基金;

关键词：

Parabacteroides goldsteinii; Outer membrane vesicles; Pentadecanoic acid; Immunoregulation; Gut-skin axis; Skin inflammatory diseases;

D O I：

10.1016/j.jconrel.2024.11.014

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Despite gut microbiota-derived extracellular vesicles (EVs) serving as pivotal mediators in bacteria-host cell interactions, their potential role in modulating skin inflammation remains poorly understood. Here, we developed strategies for mass production of Parabacteroides goldsteinii-derived outer membrane vesicles (Pg OMVs), commonly known as EVs. We found that orally administered Pg OMVs can reach the colon, traverse the intestinal barrier, and circulate to the inflamed skin of psoriasis-like mice, resulting in reduced epidermal hyperplasia, suppressed infiltration of inflammatory cells in the skin lesions, and effective amelioration of both skin and systemic inflammation. Additionally, subcutaneous injection of thermosensitive PF-127 hydrogel loaded with Pg OMVs exerts similar immunomodulatory effects, allowing sustained release of Pg OMVs into skin cells, effectively suppressing skin inflammation and ameliorating symptoms of psoriasis. This study unveils the importance of gut microbiota-derived OMVs, which can target inflamed skin via both the gut-skin axis and local skin administration, providing a promising alternative to live bacteria therapy for the treatment of skin inflammatory diseases.

引用

页码：127 / 145

页数：19