Multivariate crosstalk models

被引：0

作者：

School of Engineering, Computer Science and Mathematics, University of Exeter, United Kingdom ^{[1
]}

机构：

[1] School of Engineering, Computer Science and Mathematics, University of Exeter

来源：

Lect. Notes Comput. Sci. | 2006年 / 1129-1136期

关键词：

Crosstalk; Multivariate models; Systems biology;

D O I：

10.1007/11875581_134

中图分类号：

学科分类号：

摘要：

Since 1960s unexpected communication activity between signaling pathways and signaling molecules in cells has been very often observed. As there is no biological theory to interpret it, this activity has been termed as crosstalk, unwanted communication. So far, no computer or statistical models have been developed for modeling crosstalk between signaling proteins although studying crosstalk between signaling pathways in wet laboratory has been one of the main stream. As the first attempt in the world, we have investigated multivariate crosstalk models. The simulation shows that such statistical crosstalk models work very well although more investigations are needed. © Springer-Verlag Berlin Heidelberg 2006.

引用

页码：1129 / 1136

页数：7

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