Self-lubrication coatings were prepared by CO2 laser cladding of Ni45-CaF2-WS2 compound powders on a medium carbon steel. Microstructure and tribological properties of the laser clad coatings were investigated and analyzed. The results show that, partial WS2 powder decomposes to generate some new lubricants, such as CrxSy and CaWO4. During laser cladding process, the fluidity of laser-generated-pool has been improved by adding CaF3, the friction coefficients of coating reduce remarkably in the tribological properties test at room temperature and 400°C, and the laser cladding Ni45-7.5CaF2-7.5WS2 (mass fraction, %) coating presents lower friction coefficient and better wear resistance.