A method for continuous glucose monitoring in interstitial fluid based on microdialysis

被引：0

作者：

机构：

[1] School of Precision Instrument and Opto-Electronics Engineering, Tianjin University

来源：

Li, D. (dchli@tju.edu.cn) | 1600年 / Tianjin University卷 / 46期

关键词：

Calibration; Continuous monitoring; Glucose; Interstitial fluid; Microdialysis;

D O I：

10.11784/tdxb20130602

中图分类号：

学科分类号：

摘要：

A method based on microdialysis was presented to monitor glucose concentration in interstitial fluid to meet the requirement that the glucose concentration in interstitial fluid should be calibrated in minimally invasive blood glucose monitoring, and the influences of perfusion rate, concentration and temperature on the recovery rate of microdialysis were studied. The results led to the conclusion that the recovery rate fell by 71.7% when perfusion rate increased from 0.3 μL/min to 3.0 μL/min, different concentrations of interstitial fluid contributed little to the recovery rate, and the rise of temperature from 25°C to 58°C caused the recovery rate to increase by 34.6%. In addition, a method for simulating the rapid changes in glucose concentration in vivo was proposed, and the experimental system was established to verify the feasibility of continuous measurement of glucose level in interstitial fluid by microdialysis. All the work laid a theoretic foundation and experimental guidance for animal clinical trials in the future.

引用

页码：482 / 486

页数：4

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