Syzygium cumini leaf extract mediated green synthesis of ZnO nanoparticles: A sustained release for anticancer, antimicrobial, antioxidant, and anti-corrosive applications

ZnO nanoparticles (NPs) were synthesized with leaf extract of Syzygium cumini and spectroscopic (UV-Vis, FTIR, and NMR), microscopic (TEM), and structural characterization techniques (XRD) were used. Phyto-chemicals in leaf extract act as a capping agent which aids in the sustained release of ZnO NPs for anticancer, antioxidant, and antibacterial activities. An IC50 concentration of 49.83 mu g/ml is found in the cytotoxicity of ZnO NPs versus the HepG2 cancerous cell lines. NPs exhibited significant zones of inhibition, measuring 11.66 mm, and demonstrated minimal inhibitory concentrations (MIC) of 8.0 and 0.1 mu g ml- 1 against A. niger fungus and P. aeruginosa, bacteria, respectively. ZnO NPs also exhibited significant antioxidative action, with an IC50 of 10.54 mu g ml- 1 . ZnO NPs exhibited paramagnetic character and good anti-corrosive properties, with an impressive inhibition efficiency of 90 % at 100 ppm concentration in 1.0 M H2SO4 solution.