Effect of O6-methylguanine on the stability of G-quadruplex DNA

被引：0

作者：

Mekmaysy, Chongkham S. ^{[1
]}

Petraccone, Luigi ^{[1
,2
]}

Garbett, Nichola C. ^{[1
]}

Ragazzon, Patricia A. ^{[1
]}

Gray, Robert ^{[1
]}

Trent, John O. ^{[1
]}

Chaires, Jonathan B. ^{[1
]}

机构：

[1] James Graham Brown Cancer Center, University of Louisville, 529 South Jackson Street, Louisville, KY 40202, United States

[2] Department of Chemistry P.Corradini, University of Naples Federico II, via Cintia, 4, I-80126 Napoli, Italy

来源：

Journal of the American Chemical Society | 2008年 / 130卷 / 21期

关键词：

The effects of substitution of O6-methylguanine on the structure and stability of a human telomere quadruplex was studied by circular dichroism; thermal denaturation; analytical ultracentrifugation; and molecular dynamics simulations. The results show that; while quadruplex structures can form containing the modified base; they are much less stable than the normal unmodified structure. The extent of destabilization is critically dependent on the exact position of the modified base within the quadruplex structure. Copyright © 2008 American Chemical Society;

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摘要：

Journal article (JA)

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页码：6710 / 6711