Additive manufacturing and in vitro study of biological characteristics of sulfonated polyetheretherketone-bioactive glass porous bone scaffolds

被引：0

作者：

Zhang, Fangyu ^{[1
]}

Qu, Han ^{[1
]}

Li, Guiwei ^{[1
]}

Zhu, Xinhao ^{[1
]}

Sun, Yitong ^{[1
]}

Cao, Qiyuan ^{[1
]}

Wu, Wenzheng ^{[1
]}

机构：

[1] Jilin Univ, Sch Mech & Aerosp Engn, Changchun 130025, Jilin, Peoples R China

来源：

BIOMEDICAL MATERIALS | 2024年 / 19卷 / 06期

关键词：

fused deposition modeling; additive manufacturing; polyetheretherketone; sulfonation reaction; bioactive glass; biocompatibility; 3-DIMENSIONAL SCAFFOLDS; SURFACE;

D O I：

10.1088/1748-605X/ad8330

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Polyetheretherketone (PEEK), a high-performance special engineering plastic, has gradually been used in bone substitutes due to its wear resistance, acid and alkali resistance, non-toxicity, radiolucency, and modulus close to that of human bone. However, its stable biphenyl structure determines strong biological inertness, thus artificial interventions are required to improve the biological activity of fabricated PEEK parts for better clinical applications. This study developed a novel strategy for grafting bioactive glass (BAG) onto the surface of PEEK through sulfonation reaction with concentrated sulfuric acid (H2SO4), aiming to improve the bioactivity of printed porous bone scaffolds manufactured by fused deposition modeling to meet clinical individual needs. In vitro biological study was conducted on sulfonated PEEK-BAG scaffolds obtained by this strategy. The results demonstrated that the optimal modification condition was a 4 h sulfonation reaction with 1 mol l-1 concentrated H2SO4 at high temperature and high pressure. The scaffold obtained under this condition showed minimal cytotoxicity, and the Ca/P molar ratio, yield compressive strength, and compressive modulus of this scaffold were 2.94 +/- 0.02, 62.78 MPa, and 0.186 GPa respectively. The presented method provides an innovative, highly effective, and customized strategy to improve the biocompatibility and bone repair ability of printed PEEK bone scaffolds for virous biomedical applications.

引用

页数：17