Increased chemerin and decreased omentin-1 levels in morbidly obese patients are correlated with insulin resistance, oxidative stress and chronic inflammation

被引：31

作者：

Cătoi, Adriana Florinela ^{[1
]}

Suciu, Şoimiţa ^{[1
]}

Pârvu, Alina Elena ^{[2
]}

Copăescu, Cătălin ^{[3
]}

Galea, Romeo Florin ^{[4
]}

Buzoianu, Anca Dana ^{[5
]}

Vereşiu, Ioan Andrei ^{[6
]}

Cătoi, Cornel ^{[7
]}

Pop, Ioana Delia ^{[8
]}

机构：

[1] Department of Physiology, Faculty of Medicine, Iuliu Haţieganu University of Medicine and Pharmacy, Cluj-Napoca

[2] Department of Pathophysiology, Faculty of Medicine, Iuliu Haţieganu University of Medicine and Pharmacy, Cluj-Napoca

[3] Bariatric Center of Excellence (BariXL) Ponderas (Delta) Hospital, Bucharest

[4] Second Surgical Clinic, Faculty of Medicine, Iuliu Haţieganu University of Medicine and Pharmacy, Cluj-Napoca

[5] Department of Pharmacology, Faculty of Medicine Iuliu Haţieganu, University of Medicine and Pharmacy, Cluj-Napoca

[6] Clinical Center of Diabetes, Faculty of Medicine, Iuliu Haţieganu University of Medicine and Pharmacy, Cluj-Napoca

[7] Department of Pathology, Faculty of Veterinary Medicine, University of Agricultural Sciences and Veterinary Medicine, Cluj-Napoca

[8] Department of Exact Sciences, Faculty of Horticulture, University of Agricultural Sciences and Veterinary Medicine, Cluj-Napoca

来源：

Clujul Medical | 2014年 / 87卷 / 01期

关键词：

Adipokines; Chronic inflammation; Morbid obesity; Oxidative stress;

D O I：

10.15386/cjm.2014.8872.871.afc1

中图分类号：

学科分类号：

摘要：

Background and aim: Morbid obesity represents a proinflammatory and prooxidative state associated with dysregulation of adipokines. We aimed to evaluate the circulating levels of chemerin and omentin-1 in morbidly obese (MO) patients and to investigate the relationship between these two adipokines and between each of them and anthropometric, metabolic, oxidative stress and chronic inflammatory parameters. Material and methods: 32 MO patients and 20 controls were investigated in this study. Anthropometric, metabolism parameters, inflammatory markers, oxidative stress indicators as well as chemerin and omentin-1 were measured. Results: Serum levels of chemerin were increased while omentin-1 levels were decreased in MO patients when compared with controls. Chemerin correlated positively with insulin, HOMA-IR, LDL cholesterol and negatively with total antioxidant response. Omentin-1 correlated negatively with tumor necrosis factor alpha and total cholesterol. In a multiple linear stepwise regression analysis we learnt that only HOMA-IR (β=0.70, p<0.001), total cholesterol (β=0.42, p<0.001) and triglycerides (β=0.31, p<0.05) remained significantly associated with chemerin changes. Using the same analysis we noticed that total cholesterol (β=-0.71, p<0.001), fasting glucose (β=-0.40, p<0.05) and body mass index (BMI) (β=-0.38, p<0.05) were considered to be significant predictors for omentin-1 changes. Conclusions: Chemerin and omentin-1 synthesis was dysregulated in MO patients. Chemerin might play a role in insulin resistance and oxidative stress. Chemerin changes seemed to be predicted mainly by insulin resistance. Omentin-1 levels were inversely associated with chronic inflammation and dyslipidemia while the main modulating factors seemed to be dyslipidemia, hyperglycemia and BMI.

引用

页码：19 / 26

页数：7

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