Progress of smart material in the repair of intervertebral disc degeneration

被引：0
|
作者：
Liu, Yisi [1 ]
Hu, Jie [1 ]
Jiang, Hao [1 ]
He, Hui [1 ]
Yao, Liwei [1 ]
Chen, Qianglong [1 ]
Wang, Lijie [2 ]
Liang, Ting [1 ]
Li, Bin [1 ]
Han, Fengxuan [1 ]
机构：
[1] Orthopedic Institute, Department of Orthopedic Surgery, Medical 3D Printing Center, The First Affiliated Hospital, School of Basic Medical Sciences, Suzhou Medical College, Soochow University, Jiangsu, Suzhou,215000, China
[2] Sanitation & Environment Technology Institute of Soochow University Ltd, Jiangsu, Suzhou,215000, China
来源：
Smart Materials in Medicine | 2024年 / 5卷 / 04期
关键词：
Intervertebral disc degeneration (IVDD) is a prevalent condition leading to back and leg pain as well as chronic disability. It refers to the degeneration of intervertebral disc structure; including the nucleus pulposus; annulus fibrosus; and cartilage endplate. Along with degeneration process; these components can deteriorate; causing pain and functional impairment. To address IVDD; researchers are exploring the use of smart materials as novel therapeutic approaches. This review aims to summarize the application of various stimuli-responsive smart materials (endogenous and exogenous stimuli-responsive materials) in the repair for Intervertebral disc. These smart materials; such as responsive hydrogels; shape-memory polymers; and nanoparticle-based delivery systems; have shown considerable potential in achieving targeted drug delivery and tissue regeneration; and improving clinical outcomes. The ongoing advancement of smart materials towards successful clinical translation holds promise for improving treatment outcomes for IVDD patients; providing more effective and safer therapeutic options. © 2024 The Authors;
D O I：
10.1016/j.smaim.2024.10.001
中图分类号：
学科分类号：
摘要：
引用
收藏
页码：488 / 500
相关论文
共 50 条
  • [41] Cervical intervertebral disc degeneration and dizziness
    Tang-Hua Liu
    Yan-Qing Liu
    Bao-Gan Peng
    World Journal of Clinical Cases, 2021, 9 (09) : 2146 - 2152
  • [42] Chondrocyte senescence in intervertebral disc degeneration
    Hundal, K
    Watkins, A
    Le Maitre, CL
    Freemont, AJ
    Hoyland, JA
    JOURNAL OF PATHOLOGY, 2002, 198 : 51A - 51A
  • [43] Role of autophagy in intervertebral disc degeneration
    Kritschil, Rebecca
    Scott, Melanie
    Sowa, Gwendolyn
    Vo, Nam
    JOURNAL OF CELLULAR PHYSIOLOGY, 2022, 237 (02) : 1266 - 1284
  • [44] Genetic Therapy for Intervertebral Disc Degeneration
    Roh, Eun Ji
    Darai, Anjani
    Kyung, Jae Won
    Choi, Hyemin
    Kwon, Su Yeon
    Bhujel, Basanta
    Kim, Kyoung Tae
    Han, Inbo
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2021, 22 (04) : 1 - 14
  • [45] Molecular Mechanisms of Intervertebral Disc Degeneration
    Rider, Sean M.
    Mizuno, Shuichi
    Kang, James D.
    SPINE SURGERY AND RELATED RESEARCH, 2019, 3 (01): : 1 - 11
  • [46] Role of macrophage in intervertebral disc degeneration
    Yiming Dou
    Yiming Zhang
    Yang Liu
    Xun Sun
    Xinyu Liu
    Bin Li
    Qiang Yang
    Bone Research, 2025, 13 (01) : 15 - 34
  • [47] Genetic aspects of intervertebral disc degeneration
    Hanaei, Sara
    Abdollahzade, Sina
    Khoshnevisan, Alireza
    Kepler, Christopher K.
    Rezaei, Nima
    REVIEWS IN THE NEUROSCIENCES, 2015, 26 (05) : 581 - 606
  • [48] In vitro model for intervertebral disc degeneration
    Rashidi, Narjes
    Santin, Matteo
    Perugini, Valeria
    TISSUE ENGINEERING PART A, 2023, 29 (13-14)
  • [49] Intervertebral disc degeneration and regenerative medicine
    Farag, Mariam
    Rezk, Rogina
    Hutchinson, Hunter
    Zankevich, Alina
    Lucke-Wold, Brandon
    CLINICAL AND TRANSLATIONAL DISCOVERY, 2024, 4 (03):
  • [50] Role of macrophage in intervertebral disc degeneration
    Dou, Yiming
    Zhang, Yiming
    Liu, Yang
    Sun, Xun
    Liu, Xinyu
    Li, Bin
    Yang, Qiang
    BONE RESEARCH, 2025, 13 (01)
12345