Progress of smart material in the repair of intervertebral disc degeneration

被引：0
|
作者：
Liu, Yisi [1 ]
Hu, Jie [1 ]
Jiang, Hao [1 ]
He, Hui [1 ]
Yao, Liwei [1 ]
Chen, Qianglong [1 ]
Wang, Lijie [2 ]
Liang, Ting [1 ]
Li, Bin [1 ]
Han, Fengxuan [1 ]
机构：
[1] Orthopedic Institute, Department of Orthopedic Surgery, Medical 3D Printing Center, The First Affiliated Hospital, School of Basic Medical Sciences, Suzhou Medical College, Soochow University, Jiangsu, Suzhou,215000, China
[2] Sanitation & Environment Technology Institute of Soochow University Ltd, Jiangsu, Suzhou,215000, China
来源：
Smart Materials in Medicine | 2024年 / 5卷 / 04期
关键词：
Intervertebral disc degeneration (IVDD) is a prevalent condition leading to back and leg pain as well as chronic disability. It refers to the degeneration of intervertebral disc structure; including the nucleus pulposus; annulus fibrosus; and cartilage endplate. Along with degeneration process; these components can deteriorate; causing pain and functional impairment. To address IVDD; researchers are exploring the use of smart materials as novel therapeutic approaches. This review aims to summarize the application of various stimuli-responsive smart materials (endogenous and exogenous stimuli-responsive materials) in the repair for Intervertebral disc. These smart materials; such as responsive hydrogels; shape-memory polymers; and nanoparticle-based delivery systems; have shown considerable potential in achieving targeted drug delivery and tissue regeneration; and improving clinical outcomes. The ongoing advancement of smart materials towards successful clinical translation holds promise for improving treatment outcomes for IVDD patients; providing more effective and safer therapeutic options. © 2024 The Authors;
D O I：
10.1016/j.smaim.2024.10.001
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页码：488 / 500
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