Isolation and structural identification of lignans from Dregea sinensis Hemsl

被引：0

作者：

Jia, Shao-Hua ^{[1
]}

Lü, Fang ^{[1
]}

Dai, Rong-Ji ^{[1
]}

Meng, Wei-Wei ^{[1
]}

Chen, Yan ^{[2
]}

Deng, Yu-Lin ^{[1
]}

机构：

[1] School of Life Science, Beijing Institute of Technology, Beijing

[2] Beijing BIT&GY Pharmaceutical R&D Co. Ltd., Beijing

来源：

Beijing Ligong Daxue Xuebao/Transaction of Beijing Institute of Technology | 2015年 / 35卷 / 03期

关键词：

Asclepiadaceae; Constituent; Dregea sinensis Hemsl; Lignans; Structure identification;

D O I：

10.15918/j.tbit1001-0645.2015.03.021

中图分类号：

学科分类号：

摘要：

In order to study the chemical constituents of Dregea sinensis Hemsl, five lignans were isolated from the roots of Dregea sinensis Hemsl by AB-8 macroporous resin column, silica gel column, Sephadex LH-20 column and semi-preparative HPLC. On the basis of 1D and 2D NMR data and MS analyses, their structures were identified as 4', 4″-dihydroxy-3,3', 3″, 5,5', 5″-hexamethoxy-7,9':7',9-diepoxy-4,8″-oxy-8,8'-sesquineolignan-7″, 9″-diol (1), 4',4″-dihydroxy-3,3', 3″, 5, 5'-pentamethoxy-7,9':7', 9-diepoxy-4,8″-oxy-8,8'-sesquineo-lignan-7″, 9″-diol (2), (+)-isolariciresinol (3), erythro-guaiacylycerol-β-O-4'-coniferyl alcohol (4), diasyringaresinol (5). These compounds were isolated from this plant for the first time. ©, 2015, Beijing Institute of Technology. All right reserved.

引用

页码：326 / 330

页数：4

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