Two-dimensional metal-organic frameworks (2D-MOFs) as a carrier for enzyme immobilization: A review on design and bio-applications

被引：4

作者：

Patil, Pravin D. ^{[1
]}

Gargate, Niharika ^{[2
]}

Tiwari, Manishkumar S. ^{[3
]}

Nadar, Shamraja S. ^{[4
]}

机构：

[1] NMIMS Univ, SVKMs Narsee Monjee Inst Management Studies, Mukesh Patel Sch Technol Management & Engn, Dept Basic Sci & Humanities, Mumbai 400056, India

[2] Kolhapur Inst Technol Coll Engn, Dept Biotechnol Engn, Kolhapur 416234, India

[3] NMIMS Univ, SVKMs Narsee Monjee Inst Management Studies, Mukesh Patel Sch Technol Management & Engn, Dept Data Sci, Mumbai 400056, India

[4] Inst Chem Technol, Dept Chem Engn, Mumbai 400019, India

来源：

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES | 2025年 / 291卷

关键词：

2D MOF enzyme hybrid composites; Immobilization strategies; Catalytic performance enhancement; Molecular dynamics simulations; ULTRASENSITIVE DETECTION; NANOSHEETS; MOF; GLUCOSE; LIPASE; NANOPARTICLES; GLUCOAMYLASE; HYDROLYSIS; STRATEGIES; PLATFORMS;

D O I：

10.1016/j.ijbiomac.2024.138984

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In the realm of carriers for enzyme immobilization, the use of MOFs has accelerated owing to their exceptional porosity and stability. Among these, 2D metal-organic frameworks (2D-MOFs) have emerged as promising supports for enzyme immobilization. This review highlights advancements in their synthesis, structural properties, and functional characteristics, focusing on enhancing catalytic performance and stability. Brief insights into computational approaches for optimizing these nanostructures and their catalytic efficiency are provided. The unique synergy between 2D MOF-based nanozymes and enzymes is discussed, showcasing their potential in diverse applications. Challenges in their practical implementation, prospective solutions, and future research directions are also outlined. This review emphasizes the transformative potential of 2D MOFs, focusing on their design and bioapplications and paving the way for innovative and sustainable strategies.

引用

页数：22

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