Experimental research on fiber Bragg grating based monitor for laser thrombolysis in vitro

被引：0

作者：

State Key Laboratory of Modern Optical Instruments, Zhejiang University, Hangzhou 310027, China ^{[1
]}

不详 ^{[2
]}

机构：

[1] State Key Laboratory of Modern Optical Instruments, Zhejiang University

[2] Central Research Laboratory, Hamamatsu Photonics K.K., 5000 Hirakuchi

来源：

Zhongguo Jiguang | 2009年 / 4卷 / 1020-1024期

关键词：

Fiber Bragg grating; Fiber optics; Laser; Shock wave; Thrombolysis;

D O I：

10.3788/CJL20093604.1020

中图分类号：

学科分类号：

摘要：

The experimental investigation of the fiber Bragg grating (FBG) sensor in monitoring action for the laser thrombolysis is introduced. In laser thrombolysis, the pulsed laser is absorbed by blood, leading to cavitating bubbles. The shock wave is generated during bubble expansion and collapse. With a tunable distributed feed back (DFB) LD laser as the light source and an edge filtering demodulation, the shock wave was measured by FBG based sensing system. In experiment, the peak power of the shock wave response increases with the laser power, and the FBG responsibility for the shock wave in the blood after ablation of clot is similar to that in blood without clot. According to this similarity, whether the clot is ablated or not can be distinguished. In the in vitro experiment, the measured ablation time is 23 s.

引用

页码：1020 / 1024

页数：4

共 14 条

[1]

Liu M., Wu B., Wang W., Et al., Stroke in china: Epidemiology, prevention, and management strategies, Lancet Neurology, 6, 5, pp. 456-464, (2007)

[2]

Berlis A., Lutsep H., Barnwell S., Et al., Mechanical thrombolysis in acute ischemic stroke with endovascular photoacoustic recanalization, Stroke, 35, 5, pp. 1112-1116, (2004)

[3]

Zhang J., Zhang X., Effect factors of laser tissue ablation, Chinese J. Lasers, 34, 2, pp. 300-304, (2007)

[4]

Becker K., Endovascular treatment of acute stroke, Current Treatment Options in Neurology, 9, 6, pp. 463-469, (2007)

[5]

Rother J., CT and MRI in the diagnosis of acute stroke and their role in thrombolysis, Thrombosis Research, 103, 1, (2001)

[6]

Othonos A., Fiber Bragg gratings, Rev. Sci. Instr., 68, 12, pp. 4309-4341, (1997)

[7]

Zhang W., Liu L., Li F., Et al., Fiber Bragg grating pressure sensor with enhanced sensitivity, Chin. Opt. Lett., 5, 9, pp. 507-508, (2007)

[8]

Xiao H., Li F., Wang Y., Et al., High-resolution fiber laser sensor system, Chinese J. Lasers, 35, 1, pp. 87-91, (2008)

[9]

Yang J., Zhao Y., Ni X., Development of novel fiber Bragg grating underwater acoustic sensor, Acta Optica Sinica, 27, 9, pp. 1575-1579, (2007)

[10]

Viator J.A., Prahl S.A., Laser thrombolysis using long pulse frequency-doubled Nd:YAG lasers, Lasers in Surgery and Medicine, 25, 5, pp. 379-388, (1999)

← 1 2 →