Fmoc-amino acid-based hydrogel vehicle for delivery of amygdalin to perform neuroprotection

被引：0

作者：

Yang Z.-Y. ^{[1
]}

Zhong Y.-Y. ^{[2
]}

Zheng J. ^{[3
]}

Liu Y. ^{[3
]}

Li T. ^{[1
]}

Hu E. ^{[1
]}

Zhu X.-F. ^{[1
]}

Ding R.-Q. ^{[1
]}

Wu Y. ^{[1
]}

Zhang Y. ^{[3
]}

Tang T. ^{[1
]}

He F. ^{[4
]}

Wang S.-S. ^{[5
]}

Wang Y. ^{[1
]}

机构：

[1] Institute of Integrative Medicine, Department of Integrated Traditional Chinese and Western Medicine, Xiangya Hospital, Central South University, Changsha

[2] Department of Integrative Medicine, Huashan Hospital, Fudan University, Shanghai

[3] Key Laboratory of Hunan Province for Water Environment and Agriculture Product Safety, College of Chemistry and Chemical Engineering, Central South University, Changsha

[4] Department of General Surgery, Xiangya Hospital Central South University, Changsha

[5] Postpartum Health Care Department, Hunan Provincial Maternal and Child Health Care Hospital, Changsha

来源：

Smart Materials in Medicine | 2021年 / 2卷

基金：

中国国家自然科学基金;

关键词：

Amygdalin; Complex hydrogel; Fmoc-Tyr-OH anti-Inflammation; Neural regeneration; Self-assembly;

D O I：

10.1016/j.smaim.2020.10.004

中图分类号：

学科分类号：

摘要：

Amygdalin is widely distributed in the plant kingdom. Oral delivery of amygdalin releases hydrogen cyanide upon endogenous enzymes causing potential toxic effects to humans. Here, we fabricate Fmoc-Tyr–OH–amygdalin hydrogel (FTOA) which represents L-tyrosine derived low molecular weight hydrogelator entrapping amygdalin. Fourier Transform Infrared Spectroscopy and the Fluorescent Emission Spectrum elucidated the complexation process between the amygdalin and Fmoc-Tyr-OH (FTO). Amygdalin was sustainably released from FTOA at different pH buffer. The rheological behavior similar to the brain supported that the hydrogel tended to be a preferable neural scaffold. Moreover, animal studies showed FTOA significantly promoted neural-functional recovery. This hydrogel achieved a great decrease in damage volume according to H&E staining. Additionally, we found that FTOA enhanced tissue recovery. Simultaneously, the released amygdalin gave a markedly neural inflammatory suppression. Taken together, this study highlights that Fmoc-based gelator encapsulate amygdalin forming a stable hydrogel to perform sustained-release and improve efficacy with minimal side effects. © 2021

引用

页码：56 / 64

页数：8

共 50 条

[21] New Physical Hydrogels Based on Co-Assembling of FMOC-Amino Acids
Croitoriu, Alexandra
Nita, Loredana E.
Chiriac, Aurica P.
Rusu, Alina G.
Bercea, Maria
GELS, 2021, 7 (04)
[22] Synthesis of [Leu5]enkephalin using Fmoc-amino acid chlorides/KOAt
Gopi, HN
Babu, VVS
JOURNAL OF THE INDIAN CHEMICAL SOCIETY, 1998, 75 (09) : 511 - 513
[23] Hybrid Gels Assembled from Fmoc-Amino Acid and Graphene Oxide with Controllable Properties
Xing, Pengyao
Chu, Xiaoxiao
Li, Shangyang
Ma, Mingfang
Hao, Aiyou
CHEMPHYSCHEM, 2014, 15 (11) : 2377 - 2385
[24] A CONVENIENT METHOD FOR SYNTHESIS OF FMOC-AMINO ACID P-NITROANILIDES BASED ON ISOBUTYL CHLOROFORMATE AS A CONDENSATION AGENT
NEDEV, H
NAHARISOA, H
HAERTLE, T
TETRAHEDRON LETTERS, 1993, 34 (26) : 4201 - 4204
[25] An amino acid-based gelator for injectable and multi-responsive hydrogel
Xiong, Wei
Zhou, Hantao
Zhang, Chong
Lu, Hua
CHINESE CHEMICAL LETTERS, 2017, 28 (11) : 2125 - 2128
[26] An amino acid-based gelator for injectable and multi-responsive hydrogel
Wei Xiong
Hantao Zhou
Chong Zhang
Hua Lu
Chinese Chemical Letters, 2017, 28 (11) : 2125 - 2128
[27] Hyaluronic acid-based hydrogel for regional delivery of paclitaxel to intraperitoneal tumors
Bajaj, Gaurav
Kim, Mi Ran
Mohammed, Sulma I.
Yeo, Yoon
JOURNAL OF CONTROLLED RELEASE, 2012, 158 (03) : 386 - 392
[28] FMOC-AMINO ACID CHLORIDES-KOBT IN SOLID-PHASE PEPTIDE-SYNTHESIS
SIVANANDAIAH, KM
BABU, VVS
GANGADHAR, BP
INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY, 1994, 33 (07): : 620 - 623
[29] FMOC-AMINO ACID-CHLORIDES IN SOLID-PHASE SYNTHESIS OF OPIOID-PEPTIDES
SIVANANDAIAH, KM
BABU, VVS
RENUKESHWAR, C
INTERNATIONAL JOURNAL OF PEPTIDE AND PROTEIN RESEARCH, 1992, 39 (03): : 201 - 206
[30] Use of Fmoc-Amino acid chlorides in solid phase synthesis of peptides and peptidomimetics with difficult sequence
Bombardi, Vincent
Giannini, Giuseppe
Mastroianni, Domenico
Scarallo, Angela
Peptides 2004, Proceedings: BRIDGES BETWEEN DISCIPLINES, 2005, : 349 - 351

← 1 2 3 4 5 →