Characteristics of advanced glycation end products self-fluorescence spectra in human skin

被引：0

作者：

Zhang L. ^{[1
]}

Zhu L. ^{[1
]}

Wang Y.-K. ^{[1
]}

Xia Y.-W. ^{[1
]}

Liu Y. ^{[1
]}

Wang A. ^{[1
]}

机构：

[1] Anhui Institute of Optics and Fine Mechanics, Chinese Academy of Sciences

来源：

Faguang Xuebao/Chinese Journal of Luminescence | 2011年 / 32卷 / 09期

关键词：

Advanced glycation end product; Fluorescence spectra; Non-invasive measurement; Tissue optics;

D O I：

10.3788/fgxb20113209.0968

中图分类号：

学科分类号：

摘要：

In this study, three dimension fluorescence spectra of standard sample of Advanced Glycation End products (AGEs), and skin self-fluorescence of AGEs are analyzed. The optimal excitation wavelength for skin AGEs is 370 nm. The skin self-fluorescence of control subjects and diabetic patients are measured by an instrumentation developed by ourselves. The results show that there are three obvious emission peaks at 418, 450, 470 nm, after normalizing the fluorescence spectra. It's distinctly that the peaks around 450 nm and 470 nm are correlated with the concentration of skin AGEs. Therefore, skin self-fluorescence excited by 370 nm can be utilized to quantitatively analyze the concentration of AGEs, and are also available for clinical diagnosing of correlated diseases.

引用

页码：968 / 971

页数：3

共 16 条

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