Halogenation of β-keto-sulfones using KX/H2O2 in aqueous medium: Synthesis of α-halo β-keto-sulfones and α-halomethyl sulfones

被引：0

作者：

Natural Products Laboratory, Organic Chemistry Division-I, Indian Institute of Chemical Technology, Hyderabad 5000 07, India ^{[1
]}

机构：

[1] Natural Products Laboratory, Organic Chemistry Division-I, Indian Institute of Chemical Technology

来源：

J. Sulfur Chem. | 2007年 / 4卷 / 345-350期

关键词：

Hydrogen peroxide; Potassium halide; α-Halo; β-keto-sulfones; α-Halomethyl sulfones;

D O I：

10.1080/17415990701418738

中图分类号：

学科分类号：

摘要：

Synthesis of α-halo β-keto-sulfones and α-halomethyl sulfones is described by the reaction of β-keto-sulfones with potassium halides in the presence of hydrogen peroxide in aqueous acidic medium afforded the corresponding α-halo β-keto-sulfones at room temperature in excellent yields. Further the α-halo β-keto-sulfones on treatment of aqueous alkali underwent base-induced cleavage to yield α-halomethyl sulfones. © 2007 Taylor & Francis.

引用

页码：345 / 350

页数：5

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