Characterization of a protein using saw resonator

Surface Acoustic Wave (SAW) propagation on the surface of a piezoelectric crystal is used as a carrier of information. SAW Sensors are micro-electromechanical systems (MEMS) in which high frequency acoustic waves travel close to the surface of a piezoelectric substrate. Because of confined acoustic energy near the surface within the range of one acoustic wavelength, SAW devices are highly sensitive for surface perturbation such as molecular absorption or adsorption and change of viscoelastic properties. Surface acoustic wave (SAW) devices are very promising in providing a high-performance sensing platform with wireless and remote operational capabilities. Research focus is on studying methods to characterize conductance, susceptance, viscosity, and other properties of protein samples, like albumin using SAW related resonator devices quickly and inexpensively using quantities of less than one Nano-liter. Applied pressure or bending of the quartz sets up a condition where a separation of charge occurs (due to change in dipole moment density). The potential difference is proportional to the magnitude of stress. When a mass is deposited on the electrode the resultant decrease in resonant frequency can detect mass changes at nanogram level. We propose to advance the sensitivity of the characterization by use of quartz SAW resonators since they can operate at much higher frequency than bulk wave oscillators. © 2014 World Scientific Publishing Company.