[1] Department of Pharmaceutical Sciences, University of Perugia, via del Liceo, Perugia,1-06123, Italy
[2] Department of Experimental Medicine, University of Perugia, Perugia, Italy
[3] Department of Medicine, University of Perugia, Perugia, Italy
[4] Department of Morphology, Surgery and Experimental Medicine, University of Ferrara, Ferrara, Italy
[5] Department of Pathology and Cell Biology, University of South Florida, Tampa,FL, United States