TIL Therapy in Lung Cancer: Current Progress and Perspectives

被引:1
|
作者
Hu, Weilei [1 ,2 ,3 ]
Bian, Yifei [2 ,3 ]
Ji, Hongbin [1 ,2 ,3 ,4 ]
机构
[1] Univ Chinese Acad Sci, Hangzhou Inst Adv Study, Sch Life Sci, Key Lab Syst Hlth Sci Zhejiang Prov, Hangzhou 310024, Peoples R China
[2] Chinese Acad Sci, Shanghai Inst Biochem & Cell Biol, Ctr Excellence Mol Cell Sci, Key Lab Multicell Syst, Shanghai 200031, Peoples R China
[3] Univ Chinese Acad Sci, Beijing 100049, Peoples R China
[4] Shanghai Tech Univ, Sch Life Sci & Technol, Shanghai 200120, Peoples R China
基金
中国国家自然科学基金;
关键词
Adoptive cell transfer (ACT); Lung cancer; Non-small cell lung cancer (NSCLC); Tumor-infiltrating lymphocytes (TILs); Tumor-reactive T cells; TUMOR-INFILTRATING LYMPHOCYTES; ADOPTIVE CELL TRANSFER; REACTIVE T-CELLS; METASTATIC MELANOMA; RECOMBINANT INTERLEUKIN-2; CD4+T CELLS; PHASE-II; IN-VIVO; IMMUNOTHERAPY; ANTIGEN;
D O I
10.1002/advs.202409356
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Lung cancer remains the most prevalent malignant tumor worldwide and is the leading cause of cancer-related mortality. Although immune checkpoint blockade has revolutionized the treatment of advanced lung cancer, many patients still do not respond well, often due to the lack of functional T cell infiltration. Adoptive cell therapy (ACT) using expanded immune cells has emerged as an important therapeutic modality. Tumor-infiltrating lymphocytes (TIL) therapy is one form of ACT involving the administration of expanded and activated autologous T cells derived from surgically resected cancer tissues and reinfusion into patients and holds great therapeutic potential for lung cancer. In this review, TIL therapy is introduced and its suitability for lung cancer is discussed. Then its historical and clinical developments are summarized, and the methods developed up-to-date to identify tumor-recognizing TILs and optimize TIL composition. Some perspectives toward future TIL therapy for lung cancer are also provided. Unveiling the promise of Tumor-Infiltrating Lymphocytes (TIL) therapy for lung cancer treatment. This review introduces why TIL therapy is suitable for lung cancer, delves into its historical and clinical developments, and discusses methods for identifying tumor-recognizing TILs and optimizing TIL composition. It also provides some perspectives toward future TIL therapy for lung cancer. image
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页数:16
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