Advances and Challenges in Polymer-Based Scaffolds for Bone Tissue Engineering: A Path Towards Personalized Regenerative Medicine

被引:3
|
作者
Farjaminejad, Samira [1 ]
Farjaminejad, Rosana [1 ]
Hasani, Melika [2 ]
Garcia-Godoy, Franklin [3 ]
Abdouss, Majid [4 ]
Marya, Anand [5 ,6 ]
Harsoputranto, Ari [6 ,7 ]
Jamilian, Abdolreza [6 ,8 ]
机构
[1] City Univ London, Sch Hlth & Psychol Sci, Dept Hlth Serv Res & Management, London WC1E 7HU, England
[2] Islamic Azad Univ, Dept Biomed Engn, Cent Tehran Branch, Tehran 1955847781, Iran
[3] Univ Tennessee Hlth Sci Ctr, Coll Dent, Biosci Res Ctr, Dept Biosci Res, 875 Union Ave, Memphis, TN 38163 USA
[4] Amirkabir Univ Technol AUT, Dept Chem, Tehran 1591634311, Iran
[5] Univ Puthisastra, Fac Dent, Dent Res & Program, Orthodont, Phnom Penh, Cambodia
[6] Univ Bolton, City London Dent Sch, London BL3 5AB, England
[7] Univ Puthisastra, Fac Dent, Orthodont Dept, Phnom Penh, Cambodia
[8] Islamic Azad Univ, Fac Dent, Tehran Med Sci, Orthodont Dept, Tehran 1417935840, Iran
关键词
polymers; regenerative medicine; tissue engineering; bone regeneration; scaffolds; COMPOSITE SCAFFOLDS; POROUS SCAFFOLDS; HYALURONIC-ACID; BIOMATERIALS; DEGRADATION;
D O I
10.3390/polym16233303
中图分类号
O63 [高分子化学(高聚物)];
学科分类号
070305 ; 080501 ; 081704 ;
摘要
Polymers have become essential in advancing bone tissue engineering, providing adaptable bone healing and regeneration solutions. Their biocompatibility and biodegradability make them ideal candidates for creating scaffolds that mimic the body's natural extracellular matrix (ECM). However, significant challenges remain, including degradation by-products, insufficient mechanical strength, and suboptimal cellular interactions. This article addresses these challenges by evaluating the performance of polymers like poly(lactic-co-glycolic acid) (PLGA), polycaprolactone (PCL), and polylactic acid (PLA) in scaffold development. It also explores recent innovations, such as intelligent polymers, bioprinting, and the integration of bioactive molecules to enhance scaffold efficacy. We propose that overcoming current limitations requires a combination of novel biomaterials, advanced fabrication techniques, and tailored regulatory strategies. The future potential of polymer-based scaffolds in personalised regenerative medicine is discussed, focusing on their clinical applicability.
引用
收藏
页数:22
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